Endothelial dysfunction in type 2 diabetes mellitus
Endothelial dysfunction in type 2 diabetes mellitus
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DOI：
10.1016/j.numecd.2005.10.015
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发表时间：
2006-03-01
影响因子：
3.9
通讯作者：
de Kreutzenberg, S
中科院分区：
文献类型：
--
作者：
Avogaro, A;Fadini, GP;de Kreutzenberg, S
目的：血管内皮细胞在维持健康的心血管稳态中起着重要作用。糖尿病（DM）实质上损害内皮的血管舒张特性并导致内皮功能障碍，因此可以认为内皮功能障碍是心血管疾病进展的第一步。本研究的目的是说明可能的机制，负责内皮功能障碍DM。数据合成：我们已经表明，NADPH氧化酶基因表达增加，从DM患者的循环淋巴单核细胞，这种增加的基因表达依赖于代谢控制。高血压可通过激活蛋白激酶C介导其不良反应。我们发现DM患者单核细胞膜相关PKC β 2活性增加。在血糖正常的条件下，这种活性降低了40%。最后，我们发现减少循环内皮祖细胞，骨髓来源的内皮定向干细胞的一个子集，它可以引起成熟的内皮cells.Conclusion：内皮功能障碍，动脉粥样硬化过程的初始步骤，是可逆的。因此，不仅要控制高血糖症，还要控制心血管疾病的其他危险因素，以防止所有这些最终导致糖尿病患者过早死亡的过程的发生。(c)2005 Elsevier B.V.保留所有权利。
Aims: Vascular endothelial cells play a major role in maintaining cardiovascular homeostasis in health. Diabetes mellitus (DM) substantially impairs the vasodilating properties of the endothelium and leads to endothelial dysfunction, which can thus be considered the first step in the progression of cardiovascular disease. The aim of the present study is to illustrate possible mechanisms responsible for endothelial dysfunction in DM.Data synthesis: We have shown that NADPH oxidase gene expression is increased in circulating lymphomonocytes from patients with DM, and that this increased gene expression is dependent upon metabolic control. Hyperglycemia can mediate its adverse effects through the activation of protein kinase C. We have shown an increase in membrane-associated PKC beta 2 activity in monocytes from patients with DM. This activity was reduced by 40% in the euglycemic condition. Finally, we show a reduction of the circulating enclothelial progenitor cells, a subset of bone marrow-derived endotheliat-oriented stem cells, which can give rise to mature endothelial cells.Conclusion: Endothelial dysfunction, the initial step of the atherosclerotic process, is reversible. Thus, major efforts should be made to control not only hyperglycemia but also the other risk factors for cardiovascular disease, in order to prevent the onset of all these processes that eventually leads the diabetic patient to premature death. (c) 2005 Elsevier B.V. All rights reserved.