EFFECTS OF PRESSURE-GRADIENTS BETWEEN BRANCHES OF THE LEFT CORONARY-ARTERY ON THE PRESSURE AXIS INTERCEPT AND THE SHAPE OF STEADY-STATE CIRCUMFLEX PRESSURE-FLOW RELATIONS IN DOGS
EFFECTS OF PRESSURE-GRADIENTS BETWEEN BRANCHES OF THE LEFT CORONARY-ARTERY ON THE PRESSURE AXIS INTERCEPT AND THE SHAPE OF STEADY-STATE CIRCUMFLEX PRESSURE-FLOW RELATIONS IN DOGS
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DOI：
10.1161/01.res.56.1.11
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发表时间：
1985-01-01
影响因子：
20.1
通讯作者：
HOFFMAN, JIE
中科院分区：
文献类型：
--
作者：
MESSINA, LM;HANLEY, FL;HOFFMAN, JIE
当研究冠状动脉回旋支的稳态压力-流量关系时，它与左冠状动脉的其他分支之间会产生压力梯度。为了评估这些压力梯度的影响，在犬心脏跳动和长舒张期，比较了存在和不存在压力梯度的情况下的压力轴截距和稳态回旋压力-流量关系的形状。外周冠脉压力和放射性核素标记的微球用于评估动脉侧支循环。在心脏不停跳中，动脉内压差降低了低回旋压力时的曲率，并高估了平均压力轴截距7.8 mm Hg(P<；0.05)。对于长舒张期的压力-流量关系，结果是相似的。这种高估夸大了压力轴截距和冠状静脉窦压力之间的差异。外周冠脉压力和微球结果表明，这些影响主要是由动脉侧支血流介导的。
When steady-state pressure-flow relations are studied in the circumflex coronary artery, pressure gradients develop between it and other branches of the left coronary artery. To assess the effects of these pressure gradients, the pressure axis intercept and shape of steady-state circumflex pressure-flow relations was compared in the presence and absence of gradients after autoregulation was abolished, both in the beating heart and during long diastoles in dogs. Peripheral coronary pressures and radionuclide-labeled microspheres were used to assess arterial collateral flow. In the beating heart, intraarterial pressure gradients reduced the curvature at low circumflex pressures and overestimated the mean pressure axis intercept by 7.8 mm Hg (P < 0.05). The results were similar for the pressure-flow relations derived during long diastoles. This overestimation exaggerates the difference between the pressure axis intercept and coronary sinus pressure. The peripheral coronary pressure and microsphere results indicate that these effects are mediated largely by arterial collateral flow.