Ethanol-induced malformations in mice.
Ethanol-induced malformations in mice.
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乙醇引起的小鼠畸形。
DOI：
10.1111/j.1530-0277.1977.tb05876.x
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
Don W. Walker
中科院分区：
文献类型：
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作者：
C. L. Randall;W. Jape Taylor;Don W. Walker
妊娠第5 ~第10天，C57BL/6J小鼠饲喂以乙醇为日总能量25%的液体饲料；对照组用蔗糖代替乙醇或饲料。在其他时间，所有的老鼠都吃固定的食物。在妊娠第19天处死小鼠。给予乙醇的小鼠吸收的胎儿数量是对照组的两倍。在给予乙醇的16只小鼠中，15只至少有1个畸形胎儿，总共有31个畸形胎儿；29个对照组中只有5个胎儿畸形。在剩下的98个给予乙醇的胎儿中，31个有外部或内部异常。在对照组中，每组有3个胎儿出现异常。
From day 5 to day 10 of pregnancy, C57BL/6J mice were given a liquid diet with 25% of total daily energy supplied by ethanol; controls had sucrose to replace ethanol or a stock diet. At other times all mice had a stock diet. The mice were killed on day 19 of pregnancy. Twice as many foetuses were resorbed by mice given ethanol as by control groups. Of the 16 mice given ethanol, 15 had at least 1 malformed foetus with 31 malformed foetuses altogether; 5 only of the 29 controls had malformed foetuses. Of the remaining 98 foetuses in the group given ethanol, 31 had an external or internal anomaly. In the control groups, 3 foetuses in each had anomalies.