Brain dysfunction in anorexia nervosa: cause or consequence of under-nutrition?
Brain dysfunction in anorexia nervosa: cause or consequence of under-nutrition?
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DOI：
10.1097/yco.0b013e3283453775
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发表时间：
2011-05-01
影响因子：
6.9
通讯作者：
Sachdev, Perminder
中科院分区：
文献类型：
--
作者：
Hay, Phillipa J.;Sachdev, Perminder
综述目的证明大脑物质损失的成像研究有助于解释为什么神经性厌食症患者存在认知缺陷，并可能有助于阐明许多患者的认知方式。目前尚不清楚神经生物学的脆弱性是否易患神经性厌食症，或者这是否与疾病发展后症状的维持有关。最近的发现，来自功能性神经成像研究的证据提出了生物学异常可能易患神经性厌食症的可能性。研究发现，额叶、边缘系统、枕叶、纹状体和小脑区域的功能异常可能在康复后持续存在。然而，最近的横截面和前瞻性研究表明，改善大脑活动和混合的调查结果，关于神经认知功能与恢复从厌食nervosa.SummaryThe神经生物学厌食症的阐明受益于神经成像和认知神经科学的最新进展。需要进一步的研究来检查异常是饥饿的结果还是由假定的神经性厌食症内表型引起的程度。
Purpose of reviewImaging studies that demonstrate loss of brain substance help explain why people with anorexia nervosa have cognitive deficits and may help to elucidate the cognitive style found in many patients. It is not known whether a neurobiological vulnerability predisposes to anorexia nervosa or if this is associated with maintenance of symptoms once the illness develops.Recent findingsEvidence emerging from functional neuro-imaging studies raise the possibility of a biological abnormality that may predispose to anorexia nervosa. Studies have found abnormal functioning in the frontal, limbic, occipital, striatal and cerebellar regions that may persist after recovery. However, most recent cross-sectional and prospective studies indicate improved cerebral activity and mixed findings in regards to neurocognitve function with recovery from anorexia nervosa.SummaryThe elucidation of the neurobiology of anorexia nervosa has benefited from recent advances in neuro-imaging and cognitive neuroscience. Further research is needed to examine the degree to which abnormalities are a consequence of starvation or are caused by a putative anorexia nervosa endophenotype.