Effects of cavitation-enhanced heating in high-intensity focused ultrasound treatment on shear wave imaging
Effects of cavitation-enhanced heating in high-intensity focused ultrasound treatment on shear wave imaging
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DOI：
10.7567/jjap.54.07hf11
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发表时间：
2015-07-01
影响因子：
1.5
通讯作者：
Umemura, Shin-ichiro
中科院分区：
文献类型：
--
作者：
Iwasaki, Ryosuke;Nagaoka, Ryo;Umemura, Shin-ichiro
高强度聚焦超声（HIFU）治疗是一种侵入性较小的癌症治疗方法，其中超声在体外产生并聚焦于待热凝固的肿瘤组织。为了提高HIFU治疗的安全性、准确性和效率，已经提出了“多次触发HIFU”作为空化增强加热的方法以缩短治疗时间。在这项研究中，我们还提出了剪切波弹性成像（SWE）的非侵入性监测空化增强加热。结果表明，剪切波速度的增加，观察到在凝固区，但它是显着放缓时，空化发生。这表明，与不产生气泡的加热相比，空化增强加热在精确测量剪切模量之前需要显著更长的冷却时间。(C)2015日本应用物理学会
High-intensity focused ultrasound (HIFU) therapy is a less invasive method of cancer treatment, in which ultrasound is generated outside the body and focused at the tumor tissue to be thermally coagulated. To enhance the safety, accuracy, and efficiency of HIFU therapy, "multiple-triggered HIFU" has been proposed as a method of cavitation-enhanced heating to shorten treatment time. In this study, we also propose shear wave elastography (SWE) to noninvasively monitor the cavitation-enhanced heating. Results show that the increase in shear wave velocity was observed in the coagulation area, but it was significantly slower when cavitation occurred. This suggests that the cavitation-enhanced heating requires a significantly longer cooling time before the accurate measurement of shear modulus than heating without generating bubbles. (C) 2015 The Japan Society of Applied Physics