NEURONAL CHEMOTAXIS - CHICK DORSAL-ROOT AXONS TURN TOWARD HIGH-CONCENTRATIONS OF NERVE GROWTH-FACTOR
NEURONAL CHEMOTAXIS - CHICK DORSAL-ROOT AXONS TURN TOWARD HIGH-CONCENTRATIONS OF NERVE GROWTH-FACTOR
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DOI：
10.1126/science.493992
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发表时间：
1979-01-01
期刊：
影响因子：
56.9
通讯作者：
BARRETT, JN
中科院分区：
文献类型：
--
作者：
GUNDERSEN, RW;BARRETT, JN
将含有2 ~ 50个生物单位的β神经生长因子（β nerve growth factor，NGF）的微量移液器置于组织培养的鸡背根神经节神经元轴突附近。轴突在21分钟内转向并向NGF源生长。这种对高浓度NGF的转向反应似乎代表了趋化性指导，而不是生长速率的普遍增强。
Micropipettes containing 2 to 50 biological units of β nerve growth factor (NGF) were placed near growing axons of chick dorsal-root ganglion neurons in tissue culture. The axons turned and grew toward the NGF source within 21 minutes. This turning response to elevated concentrations of NGF appears to represent chemotactic guidance rather than a general enhancement of growth rate.