Data withholding in genetics and the other life sciences: Prevalences and predictors
Data withholding in genetics and the other life sciences: Prevalences and predictors
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DOI：
10.1097/00001888-200602000-00008
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发表时间：
2006-02-01
影响因子：
7.4
通讯作者：
Holtzman, NA
中科院分区：
文献类型：
--
作者：
Blumenthal, D;Campbell, EG;Holtzman, NA
目的为了更好地了解遗传学和其他生命科学领域中数据隐瞒的种类和流行程度，并探索与这些行为相关的因素。扣留。自变量与教师的个人特征、研究特征以及以前的数据隐瞒经验有关。数据共享和过去分享的负面经历与遗传学家或OL之间的口头或出版隐瞒显著相关。方法2000年，对美国100所研究最密集的大学的2893名遗传学家和其他生命科学家(OL)的样本进行了关于数据隐瞒和分享的调查。该仪器是在1999年开发和预试的。两个主要的结果措施是在与同事就未发表的研究进行口头交流时隐瞒(口头隐瞒)和作为出版过程的一部分隐瞒(发表隐瞒)。结果共收回1,849名教职员工(%)，其中遗传学家1,240人，OLS 600人。44%的遗传学家和32%的OLS报告说，在过去的三年里，他们参与了13种形式的数据隐瞒中的任何一种。发表保留(遗传学家35%，OLS 25%)比口头保留(遗传学家23%，OLS 12%)更频繁。在多因素分析中，男性性别、参与行业关系、导师不鼓励数据共享、接受数据共享的正式指导、以及共享的负面过去经历与遗传学家或OL之间的口头或出版隐瞒显著相关。结论数据隐瞒在生物医学中很常见，形式多样，受研究人员及其培训的各种特征的影响，并因科学领域而异。在年轻研究人员的成长经历中鼓励开放可能是增加数据共享的关键，但正规培训的效果似乎并不直接。
Purpose To better understand the variety and prevalence of data withholding in genetics and the other life sciences and to explore factors associated with these behaviors. withholding. The independent variables related to the personal characteristics, research characteristics of faculty, and previous experience with data withholding. data sharing, and negative past experience with sharing were significantly associated with either verbal or publishing withholding among either geneticists or OLS.Method In 2000, a sample of 2,893 geneticists and other life scientists (OLS) at the 100 most research-intensive universities in the United States were surveyed concerning data withholding and sharing. The instrument was developed and pretested in 1999. The two primary outcome measures were withholding in verbal exchanges with colleagues about unpublished research (verbal withholding) and withholding as part of the publishing process (publishing withholding). The independent variables related to the personal characteristics, research characteristics of faculty, and previous experience with data withholding.Results A total of 1,849 faculty responded (64%): 1,240 geneticists and 600 OLS. Forty-four percent of geneticists and 32% of OLS reported participating in any one of 13 forms of data withholding in the three previous years. Publishing withholding (geneticists 35%, OLS 25%) was more frequent than verbal withholding (geneticists 23%, OLS 12%). In multivariate analyses, male gender, participation in relationships with industry, mentors' discouraging data sharing, receipt of formal instruction in data sharing, and negative past experience with sharing were significantly associated with either verbal or publishing withholding among either geneticists or OLS.Conclusions Data withholding is common in biomedical science, takes multiple forms, is influenced by a variety of characteristics of investigators and their training, and varies by field of science. Encouraging openness during the formative experiences of young investigators may be critical to increased data sharing, but the effects of formal training do not appear straightforward.