Comparative analysis of male and female populations on prevalence and antibiotic resistance of Mycoplasma hominis in China, 2005-2014
Comparative analysis of male and female populations on prevalence and antibiotic resistance of Mycoplasma hominis in China, 2005-2014
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2005-2014年中国男女人群人型支原体患病率及耐药性比较分析
DOI：
10.1016/j.jgar.2016.03.004
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发表时间：
2016-09-01
影响因子：
4.6
通讯作者：
Zhang, Jun
中科院分区：
文献类型：
--
作者：
Kong, Yingying;Qiao, Yingli;Zhang, Jun
本研究的目的是估计男性和女性人群中人型支原体的患病率和耐药性。共检查了67921人。所有样本均从2005年1月至2014年12月的门诊患者中分离。使用支原体IST 2进行种属鉴定和抗生素敏感性试验。在本研究中，分别有523例（0.8%）和4625例（6.8%）培养物为单一M阳性。人型鉴定和同时鉴定两种M.人脲原体属（Ureaplasma spp.）结果表明，无论是单一识别还是同时识别，女性都比男性更频繁。此外，单个M. 56-60岁男性和61-65岁女性的人型识别率最高，男性>65岁和女性15-20岁的人型识别率最高。在评价的7种抗生素中，四环素、交沙霉素、强力霉素和普那霉素是最有效的，而克拉霉素、环丙沙星和氧氟沙星显示出极高的耐药率。不同性别的细菌对抗菌药物的敏感率不同，对氧氟沙星的耐药率差异有统计学意义（P < 0.05）。总之，本研究表明M.在过去的10年中，男女之间的人感染率差异很大，最佳的抗菌治疗策略应该以当地的药敏试验为指导。(C)2016年国际感染和癌症化疗学会。由爱思唯尔有限公司出版。保留所有权利。
The aim of this study was to estimate the prevalence and antimicrobial resistance rate of Mycoplasma hominis among male and female populations. A total of 67 921 individuals were examined. All samples were isolated from patients at an outpatient clinic from January 2005 to December 2014. Species identification and antibiotic susceptibility testing were performed using Mycoplasma IST2. In this study, 523 (0.8%) and 4625 (6.8%) cultures, respectively, were positive for single M. hominis identification and simultaneous identification of both M. hominis and Ureaplasma spp. The results showed that both single and simultaneous identification were more frequent in the female than the male population. Moreover, the highest positive rates of single M. hominis identification were observed in 56-60-year-old males and 61-65-year-old females, and the rates of simultaneous identification were high in males aged >65 years and females aged 15-20 years. Among the seven antibiotics assessed, tetracycline, josamycin, doxycycline and pristinamycin were the most effective, whilst clarithromycin, ciprofloxacin and ofloxacin displayed extremely high resistance rates. Different antimicrobial susceptibility rates were observed between the two sexes, and the resistance rates to ofloxacin showed a significant difference (P < 0.05). In conclusion, this study demonstrates that the prevalence of M. hominis varied significantly between the two sexes in the past 10 years and that the optimal antimicrobial therapy strategy should be directed by local susceptibility testing. (C) 2016 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.