Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation
Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation
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DOI：
10.1161/01.cir.0000155623.48408.c5
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发表时间：
2005-02-22
期刊：
影响因子：
37.8
通讯作者：
Ko, JM
中科院分区：
文献类型：
--
作者：
Roberts, WC;Ko, JM
方法和结果：我们检查了932例手术切除的狭窄的主动脉瓣，年龄在26-91岁之间(平均+/-SD，70+/-12)，没有相关的二尖瓣置换或二尖瓣狭窄的证据：共有504例(54%)先天性畸形瓣膜(单叶瓣膜46例，单瓣手术42例，双叶瓣膜458例)；417例(45%)有三尖瓣(无融合或微连合口融合)，11例(1%)瓣膜类型不明。后11个瓣膜很可能也是先天畸形。在584名男性中，343名(59%)患有单尖瓣或二尖瓣；在348名女性中，161名(46%)患有单尖瓣或二尖瓣。结论--这项大型研究的数据显示，因主动脉瓣狭窄(合并或不合并主动脉瓣反流)而行单纯主动脉瓣置换术且无相关二尖瓣狭窄或二尖瓣置换术的成年人中，潜在的先天性畸形瓣膜比三尖瓣更常见。
Background - Aortic valve stenosis (with or without aortic regurgitation and without associated mitral stenosis) in adults in the Western world has been considered in recent years to most commonly be the result of degenerative or atherosclerotic disease.Methods and Results - We examined operatively excised, stenotic aortic valves from 932 patients aged 26 to 91 years (mean +/- SD, 70 +/- 12), and none had associated mitral valve replacement or evidence of mitral stenosis: A total of 504 (54%) had congenitally malformed valves (unicuspid in 46 [unicommissural in 42; acommissural in 4] and bicuspid in 458); 417 (45%) had tricuspid valves (either absent or minimal commissural fusion); and 11 (1%) had valves of undetermined type. It is likely that the latter 11 valves also had been congenitally malformed. Of the 584 men, 343 (59%) had either a unicuspid or a bicuspid valve; of the 348 women, 161 (46%) had either a unicuspid or a bicuspid aortic valve.Conclusions - The data from this large study of adults having isolated aortic valve replacement for aortic stenosis (with or without associated aortic regurgitation) and without associated mitral stenosis or mitral valve replacement strongly suggest that an underlying congenitally malformed valve, at least in men, is more common than a tricuspid aortic valve.