Trunk-to-peripheral fat ratio predicts a subsequent blood pressure in normal-weight pubertal boys: a 3-year follow-up of the Kitakata Kids Health Study
Trunk-to-peripheral fat ratio predicts a subsequent blood pressure in normal-weight pubertal boys: a 3-year follow-up of the Kitakata Kids Health Study
复制标题
DOI：
10.1186/s12199-020-00878-1
复制
发表时间：
2020-08-20
影响因子：
4.7
通讯作者：
Nishiyama, Toshimasa
中科院分区：
文献类型：
--
作者：
Kouda, Katsuyasu;Iki, Masayuki;Nishiyama, Toshimasa
背景 关于双能 X 射线吸收测定法 (DXA) 测量的中央与外周脂肪比与儿童和成人随后的心脏代谢风险之间关系的证据有限。方法 本队列研究调查了 DXA 测量的体脂肪分布与心脏代谢参数之间的关系。来源人口为日本东北地区（喜多方市盐川地区）275名4-6年级学生（年龄9.6-12.6岁）。为了获得 155 名正常体重儿童（87 名男孩和 68 名女孩）的完整信息，进行了 3 年的跟踪调查。根据成人 BMI 值分别为 25 kg/m(2) 和 18.5 kg/m(2)，使用特定性别和特定年龄的国际体重指数 (BMI) 临界值来确定正常体重儿童。使用 DXA 测量的躯干与四肢脂肪比 (TAR) 和躯干与腿部脂肪比 (TLR) 评估身体脂肪分布。结果 在男孩中，调整基线年龄、身高、阴毛外观、SBP和全身脂肪后，随访时的收缩压（SBP）与基线TAR显着相关（β=0.24，P<0.05），调整全身脂肪等混杂因素后，SBP也与TLR显着相关（β=0.25，P<0.05）。在女孩中，血压和 TAR/TLR 之间没有显着关系。结论 正常体重男孩的体脂分布可预测随后青春期的血压水平。脂肪分布和血压之间的关系与脂肪体积无关。
Background Limited evidence exists regarding the relationship between central-to-peripheral fat ratio measured by dual-energy X-ray absorptiometry (DXA) and subsequent cardiometabolic risk in both pediatric and adult populations. Methods The present cohort study investigated the relationship between DXA-measured body fat distribution and cardiometabolic parameters. The source population was 275 4th-6th graders (aged 9.6-12.6 years) in the northeast region of Japan (Shiokawa area in Kitakata). A 3-year follow-up was conducted to obtain complete information from 155 normal-weight children (87 boys and 68 girls). Normal-weight children were identified using sex- and age-specific international cut-offs for body mass index (BMI) based on adult BMI values of 25 kg/m(2)and 18.5 kg/m(2), respectively. Body fat distribution was assessed using the trunk-to-appendicular fat ratio (TAR) and trunk-to-leg fat ratio (TLR) measured by DXA. Results In boys, systolic blood pressure (SBP) at follow-up showed a significant relationship with TAR at baseline after adjusting for age, height, pubic hair appearance, SBP, and whole body fat at baseline (beta= 0.24,P< 0.05), and SBP also showed a significant relationship with TLR after adjusting for confounding factors including whole body fat (beta= 0.25,P< 0.05). In girls, there were no significant relationships between blood pressure and TAR/TLR. Conclusion Body fat distribution in normal-weight boys predicted subsequent blood pressure levels in adolescence. The relationship between fat distribution and blood pressure was independent of fat volume.