Plasma Angiopoietin-Like Protein 2 Levels and Mortality Risk Among Younger-Old Japanese People: A Population-Based Case?Cohort Study
Plasma Angiopoietin-Like Protein 2 Levels and Mortality Risk Among Younger-Old Japanese People: A Population-Based Case?Cohort Study
复制标题
日本年轻老年人血浆血管生成素样蛋白 2 水平与死亡风险：基于人群的病例队列研究
DOI：
10.1093/gerona/glac017
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Tamakoshi Akiko
中科院分区：
文献类型：
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作者：
Zhao Wenjing;Morinaga Jun;Ukawa Shigekazu;Endo Motoyoshi;Yamada Hiroya;Kawamura Takashi;Wakai Kenji;Tsushita Kazuyo;Ando Masahiko;Suzuki Koji;Oike Yuichi;Tamakoshi Akiko
老龄化是一个重要的医学和社会问题。过度的血管生成素样蛋白（ANGPTL）-2信号转导导致慢性组织炎症，促进衰老相关疾病的发展和进展。此外，据报道，循环ANGPTL 2水平可预测某些衰老相关疾病和随后死亡的风险。然而，到目前为止，还没有关于循环ANGPTL 2水平是否能预测老年社区居住人群的生命预后的报道。本研究调查了该人群血浆ANGPTL 2水平与全因和特异性原因死亡率之间的相关性。该病例队列研究摘自一项正在进行的、特定年龄的前瞻性队列研究：新综合郊区老年调查项目。该项目从1996年至2005年招募了3073名年龄在64岁的参与者。一个由714名随机抽样的参与者和387名代表死亡参与者的病例组成的子队列在2015年进行了生存分析。在调整性别、吸烟、饮酒、步行时间、睡眠时间、热量摄入、医疗状况、疾病史、BMI和甘油三酯、肌酐、尿酸和高敏C反应蛋白水平后，血浆ANGPTL 2浓度分别与全因死亡率和癌症死亡率风险增加>80%和100%呈正相关。ANGPTL 2水平与全因死亡率和癌症死亡率之间的关联在虚弱或酗酒或吸烟的生活方式的参与者中更为明显。血浆ANGPTL 2水平升高与社区居住的老年人样本中的高全因死亡率和癌症死亡率相关。这些发现扩展了我们对人类衰老和相关疾病的认识。
Aging is an important medical and social problem. Excessive angiopoietin-like protein (ANGPTL)-2 signaling causes chronic tissue inflammation, promoting development and progression of aging-related diseases. Moreover, circulating ANGPTL2 levels reportedly predict the risk of some aging-related diseases and subsequent death. However, there are, as yet, no reports of whether circulating ANGPTL2 levels predict vital prognosis in younger-old, community-dwelling populations. This study investigated associations between plasma ANGPTL2 levels and all-cause and specific-cause mortality in this population. The case–cohort study was abstracted from an ongoing, age-specific prospective cohort study: the New Integrated Suburban Seniority Investigation Project. This project enrolled 3 073 participants aged 64 years at the beginning of the investigation from 1996 through 2005. A subcohort of 714 randomly sampled participants plus 387 cases representing deceased participants followed through 2015 underwent survival analysis. Plasma ANGPTL2 concentrations were positively associated with >80% and 100% higher risk of all-cause mortality and cancer mortality, respectively, after adjustment for gender, smoking, alcohol consumption, walking time, sleep duration, caloric intake, medical status, disease history, BMI, and triglyceride, creatinine, uric acid, and high sensitivity C-reactive protein levels. A more robust association between ANGPTL2 levels and all-cause and cancer mortality was seen in participants with either frailties or with lifestyles of heavier drinking or current smoking. Elevated plasma ANGPTL2 levels are associated with high all-cause and cancer mortality in a community-dwelling sample of younger-old adults. These findings expand our knowledge of human aging and associated diseases.