MicroRNAs in muscle differentiation: lessons from Drosophila and beyond.
MicroRNAs in muscle differentiation: lessons from Drosophila and beyond.
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DOI：
10.1016/j.gde.2006.08.010
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发表时间：
2006-10
影响因子：
4
通讯作者：
Hanh T. Nguyen;M. Frasch
中科院分区：
文献类型：
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作者：
Hanh T. Nguyen;M. Frasch
在广泛的生物体中观察到microRNAs的中胚层和肌肉特异性表达，这表明microRNAs的转录后调控可以显著地促进肌肉发育和生理的调节。其中一个microrna， miR-1，是在进化过程中最广泛保守的microrna之一。miR-1基因失活在果蝇中表明，miR-1对于维持快速生长阶段体壁肌肉的发育和完整性至关重要，而对于正常的中胚层模式和肌肉规范则不需要。对大量潜在的miR-1靶mrna的表达分析表明，这些mrna倾向于在非肌肉组织中表达，其模式与miR-1相互排斥。总之，这些发现支持了miR-1通过阻断混杂表达的有害mrna在肌肉发育过程中发挥“质量控制”的假设。其他mirna可能在肌肉发育和再生过程中促进特定的发育开关。
The mesoderm- and muscle-specific expression of microRNAs observed in a wide range of organisms suggests that post-transcriptional regulation by microRNAs can contribute significantly to the regulation of muscle development and physiology. One of these microRNAs, miR-1, is among the most widely conserved microRNAs during evolution. Genetic inactivation of miR-1 in Drosophila has shown that miR-1 is essential for maintaining the development and integrity of body wall muscles during phases of rapid growth, whereas it is not needed for normal mesoderm patterning and muscle specification. Expression analysis of a large set of potential miR-1 target mRNAs has revealed that these mRNAs tend to be expressed in non-muscle tissues, in patterns that are mutually exclusive with miR-1. Together, these findings lend support to the hypothesis that miR-1 exerts ‘quality control’ during muscle development by blocking detrimental mRNAs that are promiscuously expressed. Other miRNAs might promote specific developmental switches during the development and regeneration of muscles.