A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression
A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression
复制标题
DOI：
10.1016/j.neuroimage.2012.04.005
复制
发表时间：
2012-07-02
期刊：
影响因子：
5.7
通讯作者：
Flor, Herta
中科院分区：
文献类型：
--
作者：
Diener, Carsten;Kuehner, Christine;Flor, Herta
重度抑郁症（MDD）的特征是情绪和认知功能的改变。我们对1998年至2010年间发表的40篇英文同行评议研究进行了基于体素的全脑功能神经影像学数据荟萃分析，这些研究在认知-情绪挑战中使用功能神经影像学对MDD成年患者和健康对照进行了研究。所有研究均报告了标准化神经解剖空间中全脑分析的组间差异，并进行了脑簇的激活似然估计（ALE），显示MDD的反应性改变。ALE导致阈值和错误发现率校正的低和高活性脑regions. On复杂的神经激活模式的背景下，研究集中在前岛和喙前扣带皮层与情感偏见的信息处理和认知控制差的主要低活性集群。在认知情绪挑战中，额叶不仅表现出类似的低激活，而且表现出过度激活。在皮层下水平，我们确定了丘脑和纹状体的激活改变，这涉及到偏见的情绪刺激的效价加工在MDD。这些活动性条件的结果扩展了静息状态和抗抑郁治疗研究的ALE荟萃分析结果，并强调了前岛叶和头端前扣带皮层在MDD中改变情绪和认知的关键作用。(c)2012 Elsevier Inc. All rights reserved.
Major depressive disorder (MDD) is characterized by altered emotional and cognitive functioning. We performed a voxel-based whole-brain meta-analysis of functional neuroimaging data on altered emotion and cognition in MOD.Forty peer-reviewed studies in English-language published between 1998 and 2010 were included, which used functional neuroimaging during cognitive-emotional challenge in adult individuals with MDD and healthy controls. All studies reported between-groups differences for whole-brain analyses in standardized neuroanatomical space and were subjected to Activation Likelihood Estimation (ALE) of brain cluster showing altered responsivity in MDD. ALE resulted in thresholded and false discovery rate corrected hypo- and hyperactive brain regions.Against the background of a complex neural activation pattern, studies converged in predominantly hypoactive cluster in the anterior insular and rostral anterior cingulate cortex linked to affectively biased information processing and poor cognitive control. Frontal areas showed not only similar under- but also overactivation during cognitive-emotional challenge. On the subcortical level, we identified activation alterations in the thalamus and striatum which were involved in biased valence processing of emotional stimuli in MDD. These results for active conditions extend findings from ALE meta-analyses of resting state and antidepressant treatment studies and emphasize the key role of the anterior insular and rostral anterior cingulate cortex for altered emotion and cognition in MDD. (c) 2012 Elsevier Inc. All rights reserved.