A research agenda for helminth diseases of humans: diagnostics for control and elimination programmes.
A research agenda for helminth diseases of humans: diagnostics for control and elimination programmes.
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DOI：
10.1371/journal.pntd.0001601
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发表时间：
2012
影响因子：
3.8
通讯作者：
Basáñez MG
中科院分区：
文献类型：
--
作者：
McCarthy JS;Lustigman S;Yang GJ;Barakat RM;García HH;Sripa B;Willingham AL;Prichard RK;Basáñez MG
适用于采取干预措施控制寄生虫感染的诊断工具是取得成功的关键。许多寄生虫感染诊断试验的性能特点不令人满意，不太适合在日益实施的寄生虫控制规划中使用。尽管应用现代实验室研究技术来改进蠕虫感染的诊断已经取得了一些技术进步，但吸收情况并不统一。通常，对有前景的诊断技术进行试点或概念验证研究之后，并没有进行急需的产品开发，而且在许多情况下，诊断仍然依赖于不敏感和不令人满意的寄生虫学或血清诊断技术。相比之下，基于聚合酶链反应的节肢动物载体异种监测，以及使用寄生虫重组蛋白作为血清诊断测试试剂，在控制特定寄生虫方面取得了重大进展。由热带病研究和培训特别规划（热带病研究和培训特别规划）于2009年设立的蠕虫感染疾病参考小组（DRG4）的任务是审查蠕虫病研究并确定研究重点和差距。本文综述了与控制寄生虫感染有关的诊断技术，无论是现有的还是正在开发的。确定了关键差距，并讨论了改进所需技术的机会。
Diagnostic tools appropriate for undertaking interventions to control helminth infections are key to their success. Many diagnostic tests for helminth infection have unsatisfactory performance characteristics and are not well suited for use in the parasite control programmes that are being increasingly implemented. Although the application of modern laboratory research techniques to improve diagnostics for helminth infection has resulted in some technical advances, uptake has not been uniform. Frequently, pilot or proof of concept studies of promising diagnostic technologies have not been followed by much needed product development, and in many settings diagnosis continues to rely on insensitive and unsatisfactory parasitological or serodiagnostic techniques. In contrast, PCR-based xenomonitoring of arthropod vectors, and use of parasite recombinant proteins as reagents for serodiagnostic tests, have resulted in critical advances in the control of specific helminth parasites. The Disease Reference Group on Helminths Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR) was given the mandate to review helminthiases research and identify research priorities and gaps. In this review, the diagnostic technologies relevant to control of helminth infections, either available or in development, are reviewed. Critical gaps are identified and opportunities to improve needed technologies are discussed.