Determining the distribution of pharmaceutically active compounds (PhACs) in soils and sediments by pressurized hot water extraction (PHWE)
Determining the distribution of pharmaceutically active compounds (PhACs) in soils and sediments by pressurized hot water extraction (PHWE)
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DOI：
10.1016/j.chemosphere.2017.07.094
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发表时间：
2017-10-01
期刊：
影响因子：
8.8
通讯作者：
Lara-Martin, Pablo A.
中科院分区：
文献类型：
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作者：
Biel-Maeso, Miriam;Corada-Fernandez, Carmen;Lara-Martin, Pablo A.
环境中药物活性化合物（PhAC）的存在可能对人类和生态系统构成潜在风险。污水处理厂（WWTPs）被认为是这些化学品进入水生和陆地环境的主要来源之一。该研究的目的是确定存在的各种各样的PhAC（n = 45）在污水影响的沉积物和土壤从瓜达莱特河流域（西班牙西南部）通过开发和应用一种环境友好的多残留方法的基础上加压热水提取（PHWE）。对提取温度、pH值、溶剂、净化等工艺参数进行了优化。提取回收率取决于分析物，当在100 ℃下使用纯水作为提取溶剂时，大多数分析物的提取回收率在50%和140%之间变化。通过超高效液相色谱串联质谱法（UPLC-MS/MS）进行PhAC测定，使方法检测（mLOD）和定量（mLOQ）限值介于
The occurrence of pharmaceutically active compounds (PhACs) in the environment may pose a potential risk for humans and ecosystems. Wastewater treatment plants (WWTPs) are recognized as one of the main sources of these chemicals into both aquatic and terrestrial environments. The objectives of the study were to determine the presence of a wide variety of PhACs (n = 45) in sewage-impacted sediments and soils from the Guadalete River basin (SW Spain) by developing and applying an environmentally friendly multi-residue method based on pressurized hot water extraction (PHWE). Different parameters were optimized, including extraction temperature, pH, solvents, and clean-up. Extraction recoveries were analyte dependent, varying between 50% and 140% for most of the analytes when using pure water as extraction solvent at 100 degrees C. Determination of PhACs was performed by ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), enabling method detection (mLODs) and quantification (mLOQs) limits between