Urinary bladder irritation alters efficacy of vagal stimulation on rostral medullary neurons in chronic T8 spinalized rats.
Urinary bladder irritation alters efficacy of vagal stimulation on rostral medullary neurons in chronic T8 spinalized rats.
复制标题
膀胱刺激改变了迷走神经刺激对慢性 T8 脊髓化大鼠头端髓质神经元的功效。
DOI：
10.1089/neu.2007.0276
复制
发表时间：
2007
影响因子：
4.2
通讯作者：
Hubscher,CharlesH
中科院分区：
文献类型：
--
作者：
Kaddumi,EzidinG;Hubscher,CharlesH
The presence of pelvic visceral inputs to neurons in the rostral medulla that are responsive to electrical stimulation of the abdominal branches of the vagus nerve (VAG-abd) was investigated in a complete chronic T8 spinal transection rat model. Using extracellular electrophysiological recordings from single medullary reticular formation (MRF) neurons, 371 neurons in 15 rats responsive to pinching the ear (search stimulus) were tested for somato-visceral and viscero-visceral convergent responses to stimulation of the following nerves/territories: VAG-abd, dorsal nerve of the penis, pelvic nerve, distention of urinary bladder and colon, penile stimulation, urethral infusion, and touch/pinch of the entire body surface. In addition to these mechanical and electrical stimuli, a chemical stimulus applied to the bladder was assessed as well. Of the total neurons examined, 205 were tested before and 166 tested beginning 20 min after application of a chemical irritant (2% acetic acid) to the urinary bladder (same rats used pre/post irritation). As with intact controls, many ear-responsive MRF neurons responded to the electrical stimulation of VAG-abd. Although MRF neuron responses failed to be evoked with direct (mechanical and electrical nerve) pelvic visceral stimuli, acute chemical irritation of the urinary bladder produced a significant increase in the number of MRF neurons responsive to stimulation of VAG-abd. The results of this study indicate a central effect that potentially relates to some of the generalized below level pelvic visceral sensations that have been documented in patients with complete spinal cord injury.
登录
查看更多内容
狗膀胱扩张对传出心脏迷走神经纤维的影响。
影响因子：
--
作者：
A. A. Hassan;M. N. Hicks;G. E. Walters;D. Mary
通讯作者：
D. Mary
生殖、胃肠道和泌尿道之间的跨器官相互作用：动情阶段的调节和腹下神经的参与。
DOI：
10.1152/ajpregu.00455.2006
发表时间：
2006
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
Winnard,KennethP;Dmitrieva,Natalia;Berkley,KarenJ
通讯作者：
Berkley,KarenJ
大鼠脊髓中辣椒素敏感性膀胱传入神经的分布
影响因子：
2.9
作者：
G. Jancsó;C. Maggi
通讯作者：
C. Maggi
髓质网状形成神经元对男性生殖器输入的反应。
DOI：
10.1152/jn.1996.76.4.2474
发表时间：
1996
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Hubscher,CH;Johnson,RD
通讯作者：
Johnson,RD
DOI：
--
发表时间：
1991-09
期刊：
Archives internationales de physiologie, de biochimie et de biophysique
影响因子：
--
作者：
A. Jean
通讯作者：
A. Jean