Vitamin D and breast cancer recurrence in the Women's Healthy Eating and Living (WHEL) Study
Vitamin D and breast cancer recurrence in the Women's Healthy Eating and Living (WHEL) Study
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DOI：
10.3945/ajcn.2010.30009
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发表时间：
2011-01-01
影响因子：
7.1
通讯作者：
Pierce, John P.
中科院分区：
文献类型：
--
作者：
Jacobs, Elizabeth T.;Thomson, Cynthia A.;Pierce, John P.
Background: There is a paucity of research evaluating the relation between vitamin D and recurrence of breast cancer after treatment.Objective: This study was designed to evaluate the associations between circulating concentrations of 25-hydroxyvitamin D [25 (OH) D] and dietary, supplemental, and total intake of vitamin D and recurrent or new breast cancer events within the Women's Healthy Eating and Living (WHEL) Study.Design: A prospective cohort study design (n = 3085) was used to evaluate the relation between dietary, supplemental, and total vitamin D intake and recurrent breast cancer, and a nested case-control study with 512 matched pairs was used for analysis of the association between 25(OH) D and breast cancer recurrence.Results: No relation between 25(OH) D and breast cancer recurrence was observed. Compared with women with serum concentrations of 25(OH) D >= 30 ng/mL, adjusted odds ratios (95% CI) for breast cancer recurrence were 1.14 (0.57, 2.31) for those with concentrations = 10 and = 20 and
