Prostaglandin I2 and T Regulatory Cell Function: Broader Impacts.
Prostaglandin I2 and T Regulatory Cell Function: Broader Impacts.
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前列腺素 I2 和 T 调节细胞功能：更广泛的影响。
DOI：
10.1089/dna.2021.0515
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发表时间：
2021
影响因子：
3.1
通讯作者：
Peebles,RStokes
中科院分区：
文献类型：
--
作者：
Norlander,AllisonE;Peebles,RStokes
调节性细胞 (Treg) 是适应性免疫系统的重要成员，具有减少和解决炎症的功能。前列腺素 I2 (PGI2) 是一种脂质介质，对免疫细胞具有有效的抗炎作用。多项研究调查了 PGI2 和 Tregs 之间的相互作用。总之，这些研究的数据表明 PGI2 促进 Tregs 的形成和功能。这表明治疗性补充PGI2可能通过增强Treg功能来治疗各种自身免疫或炎症性疾病。
Tregulatory cells (Tregs) are an important member of the adaptive immune system and function to reduce and resolve inflammation. Prostaglandin I2(PGI2) is a lipid mediator that has potent anti-inflammatory effects on immune cells. Several studies have investigated the interplay between PGI2and Tregs. Together, the data from these studies demonstrate that PGI2promotes the formation and function of Tregs. This suggests that therapeutic supplementation of PGI2may be a treatment for various autoimmune or inflammatory diseases through enhancement of Treg function.