Avidity and titer of immunoglobulin G subclasses to Porphyromonas gingivalis in adult periodontitis patients.
Avidity and titer of immunoglobulin G subclasses to Porphyromonas gingivalis in adult periodontitis patients.
复制标题
成人牙周炎患者免疫球蛋白 G 亚类对牙龈卟啉单胞菌的亲和力和滴度。
DOI：
10.1111/j.1399-302x.1992.tb00632.x
复制
发表时间：
1992
影响因子：
--
通讯作者：
Blackburn,E
中科院分区：
文献类型：
--
作者：
Lopatin,DE;Blackburn,E
The relative avidity and titer of antibodies representing the 4 immunoglobulin G (IgG) subclasses (IgGl‐4) reactive withPorphyromonas gingivalis, P. gingivalis‐lipopolysaccharide(‐LPS), streptokinase (SK) and tetanus toxoid (TT) in the sera of patients having adult periodontitis and of healthy controls were measured. Patient antibody titers toP. gingivalisandP. gingivalis‐LPS were found to be significantly elevated for IgG, IgGl (noP. gingivalis‐LPS antibodies) and IgG2. The predominant antibody response toP. gingivalisandP. gingivalis‐LPS occurred in the IgG2 subclass. When the relative avidity of the antibodies toP. gingivalisandP. gingivalis‐LPS were examined, no significant differences between control and patient sera could be identified. However, anti‐P. gingivalisandP. gingivalis‐LPS antibodies were found to possess significantly lower relative avidity than either SK or TT antibodies. The IgGl subclass antibodies toP. gingivalis, SK and TT all appeared to be of high relative avidity. In contrast, anti‐P. gingivalisandP. gingivalis‐LPS of the IgG2 subclass were of significantly lower relative avidity. Since the predominant humoral response toP. gingivalisoccurs in the IgG2 subclass, the low relative avidity of these antibodies predominates in measurements of whole serum activity.
