Measuring the human retinal oxygenation response to a hyperoxic challenge using MRI: Eliminating blinking artifacts and demonstrating proof of concept
Measuring the human retinal oxygenation response to a hyperoxic challenge using MRI: Eliminating blinking artifacts and demonstrating proof of concept
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DOI：
10.1002/mrm.1206
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发表时间：
2001-08-01
影响因子：
3.3
通讯作者：
Gross, J
中科院分区：
文献类型：
--
作者：
Berkowitz, BA;McDonald, C;Gross, J
在实验模型中，使用MRI测量的对高氧挑战的视网膜氧合反应似乎是视网膜病变风险的早期和准确的标志物，具有很好的临床潜力。然而，这种技术在人类中的应用受到闪烁伪影的限制，闪烁伪影会混淆对细微信号强度变化的检测。我们要求受试者在12秒的快速低角度拍摄（FLASH）图像期间避免眨眼，并在接下来的3秒休息期间根据需要眨眼。在室内空气或100%氧气呼吸期间，连续重复该无眨眼眨眼周期20次。在10分钟高氧吸入激发后，从所得到的无闪烁伪影图像中首次检测到视网膜前玻璃体氧分压（上限约为13 mm Hg（1.8 KPa，N = 3））的显著变化（P < 0.05）。这些结果提供了未来MRI评估视网膜氧合反应和人类视网膜病变（如糖尿病视网膜病变）所需的概念验证数据。(C)2001 Wiley-Liss，Inc.
The retinal oxygenation response to a hyperoxic challenge measured using MRI appears to be an early and accurate marker of retinopathy risk in experimental models, with promising clinical potential. However, the application of this technique in humans is limited by blinking artifacts that can confound detection of subtle signal intensity changes. We asked subjects to refrain from blinking during a 12-s fast low-angle shot (FLASH) image, and to blink if needed during the following 3-s rest period. This no-blink blink cycle was repeated sequentially 20 times during either room-air or 100% oxygen breathing. Significant change (P < 0.05) was detected for the first time from the resultant blinking-artifact-free images in the preretinal vitreous oxygen tension (upper limit of about 13 mm Hg (1.8 KPa, N = 3)) following a 10-min hyperoxic inhalation challenge. These results provide the proof-of-concept data needed for future MRI evaluation of the retinal oxygenation response and human retinopathy, such as diabetic retinopathy. (C) 2001 Wiley-Liss, Inc.