Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions.
Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions.
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DOI：
10.1007/s10195-008-0021-7
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发表时间：
2008-09
影响因子：
2.8
通讯作者：
Milano, Carlo
中科院分区：
文献类型：
--
作者：
Galasso, Olimpio;Mariconda, Massimo;Romano, Gaetano;Capuano, Nicola;Romano, Luigi;Ianno, Bruno;Milano, Carlo
本文报告了可膨胀自锁髓内钉和富含血小板血浆凝胶(PRP)治疗长骨骨不连的X线平片和功能结果。22例萎缩性骨干长骨骨不连患者纳入研究。患者接受的治疗方法是取出原有的支架，剥离骨不连的碎片，并用可膨胀的髓内钉固定假关节(以色列特拉维夫的Fixion™，Disc‘o Tech)。在手术中，PRP被放置在假关节边缘。13个月的随访显示，91%(20/22例)的患者骨性愈合。平均愈合时间为21.5周。未发现感染、神经血管并发症、旋转排列不良或肢体缩短4 mm。骨不连的愈合率与先前研究中观察到的相似，但并发症发生率较低。自锁髓内钉与PRP联合应用治疗萎缩性骨干长骨骨不连的疗效与以往报道的相似，并发症较少。进一步的数据可以用来研究PRP凝胶和Fixion钉的单独作用。
Roentgenographic and functional outcomes of expandable self locking intramedullary nailing and platelet rich plasma (PRP) gel in the treatment of long bone non-unions are reported. Twenty-two patients suffering from atrophic diaphyseal long bone non-unions were enrolled in the study. Patients were treated with removal of pre-existing hardware, decortication of non-union fragments, and fixation of pseudoarthrosis with expandable intramedullary nailing (Fixion™, Disc’O Tech, Tel Aviv, Israel). At surgery, PRP was placed in the pseudoarthrosis rim. The thirteen-month follow-up showed 91% (20/22 patients) of patients attaining bony union. The average time to union was 21.5 weeks. No infection, neurovascular complication, rotational malalignment, or limb shortening >4 mm were observed. The healing rate of non-unions was comparable to that observed in previous studies but with a lower complication frequency. The combined use of self locking intramedullary nailing and PRP in the management of atrophic diaphyseal long bone non-unions seems to produce comparable results with less complications than previously reported. Further data are warranted to investigate the single contribution of PRP gel and Fixion nail.