A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria
A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria
复制标题
DOI：
10.5555/uri:pii:s0022534705612669
复制
发表时间：
2004-03
期刊：
影响因子：
56.9
通讯作者：
Dekai Zhang;Guolong Zhang;M. Hayden;M. Greenblatt;C. Bussey;R. Flavell;S. Ghosh
中科院分区：
文献类型：
--
作者：
Dekai Zhang;Guolong Zhang;M. Hayden;M. Greenblatt;C. Bussey;R. Flavell;S. Ghosh
toll样受体（TLRs）识别微生物所显示的分子模式，其随后的激活导致适当的宿主防御基因的转录。在这里，我们报道了哺乳动物TLR家族成员TLR11的克隆和表征，TLR11在巨噬细胞和肝脏、肾脏和膀胱上皮细胞中表现出独特的表达模式。表达TLR11的细胞不能对已知的TLR配体产生反应，而是对尿路致病菌产生特异性反应。缺乏TLR11的小鼠极易受到尿路致病菌的感染，这表明TLR11在预防泌尿生殖系统内部器官感染方面可能具有重要作用。
Toll-like receptors (TLRs) recognize molecular patterns displayed by microorganisms, and their subsequent activation leads to the transcription of appropriate host-defense genes. Here we report the cloning and characterization of a member of the mammalian TLR family, TLR11, that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells. Cells expressing TLR11 fail to respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. Mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating a potentially important role for TLR11 in preventing infection of internal organs of the urogenital system.