Have We Neglected the Role of Fetal Endothelium in Transplacental Transport?
Have We Neglected the Role of Fetal Endothelium in Transplacental Transport?
复制标题
DOI：
10.1111/tra.12130
复制
发表时间：
2014-01-01
期刊：
影响因子：
4.5
通讯作者：
Hod, Moshe
中科院分区：
文献类型：
--
作者：
Elad, David;Levkovitz, Riki;Hod, Moshe
营养物质和其他物质的母体向胎儿的转移发生在胎盘屏障（PB）上，胎盘屏障由胎儿侧的内皮细胞（EC）和母体侧的合体滋养层（STB）组成。人们进行了大量研究来探索 STB 层的运输特性，这也被认为是母婴物质交换的主要阻力。相比之下，EC 层几乎没有受到关注（如果有的话）。最近开发的可行的 PB 共培养模型揭示了 EC 层对母体向胎儿转移葡萄糖的显着阻力。这证明了 EC 对营养物质整体经胎盘转移的主要贡献。因此，建议填补知识空白并扩大我们对胎儿胎盘内皮在经胎盘运输特性中的作用的理解。
Maternal-to-fetal transfer of nutrient and other substances occurs across the placental barrier (PB) which is made up of endothelial cells (EC) on the fetal side and the syncytiotrophoblast (STB) on the maternal side. Numerous studies were conducted to explore the transport characteristics across the STB layer, which is also considered as the major resistance for maternal-to-fetal exchange of materials. In contrast the layer of EC has received very little attention if at all. A recently developed viable co-culture model of the PB revealed significant resistance of the EC layer for maternal-to-fetal transfer of glucose. This argues for a major contribution of the EC to overall transplacental transfer of nutrients. Accordingly, it is recommended to fill the void of knowledge and expand our understanding on the role of the feto-placental endothelium for transplacental transport characteristics.