The Genomics Education Partnership: Successful Integration of Research into Laboratory Classes at a Diverse Group of Undergraduate Institutions
The Genomics Education Partnership: Successful Integration of Research into Laboratory Classes at a Diverse Group of Undergraduate Institutions
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DOI：
10.1187/09-11-0087
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发表时间：
2010-03-01
影响因子：
3.7
通讯作者：
Elgin, Sarah C. R.
中科院分区：
文献类型：
--
作者：
Shaffer, Christopher D.;Alvarez, Consuelo;Elgin, Sarah C. R.
基因组学不仅对学生理解生物学至关重要，而且为本科生研究提供了前所未有的机会。基因组学教育伙伴关系（GEP）是全国越来越多的学院和大学与圣路易斯华盛顿大学生物学系和基因组中心之间的合作，其目标是提供此类研究机会。使用已适应许多不同的班级设置的多功能课程，GEP本科生承担项目，使草案质量的基因组序列达到高质量和/或参与这些序列的注释。GEP的本科生已经改进了来自几种果蝇的基因组序列草案的200多万个碱基，并使用基于证据的手动注释制作了数百个基因模型。学生赞赏他们的能力，使正在进行的研究作出贡献，并报告增加独立性和更积极的学习方法后，参与GEP项目。他们展示了关于基因和基因组以及生物信息学分析的课程前和课程后测验的知识增益。参与教师还报告专业收益，增加获得基因组学相关技术，以及整体积极的经验。我们发现，使用基因组学研究项目作为实验室课程的核心是有益的教师和学生。
Genomics is not only essential for students to understand biology but also provides unprecedented opportunities for undergraduate research. The goal of the Genomics Education Partnership (GEP), a collaboration between a growing number of colleges and universities around the country and the Department of Biology and Genome Center of Washington University in St. Louis, is to provide such research opportunities. Using a versatile curriculum that has been adapted to many different class settings, GEP undergraduates undertake projects to bring draft-quality genomic sequence up to high quality and/or participate in the annotation of these sequences. GEP undergraduates have improved more than 2 million bases of draft genomic sequence from several species of Drosophila and have produced hundreds of gene models using evidence-based manual annotation. Students appreciate their ability to make a contribution to ongoing research, and report increased independence and a more active learning approach after participation in GEP projects. They show knowledge gains on pre- and postcourse quizzes about genes and genomes and in bioinformatic analysis. Participating faculty also report professional gains, increased access to genomics-related technology, and an overall positive experience. We have found that using a genomics research project as the core of a laboratory course is rewarding for both faculty and students.