In vitro release dynamics of an anticancer drug from swellable gelatin nanoparticles
In vitro release dynamics of an anticancer drug from swellable gelatin nanoparticles
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DOI：
10.1002/app.23761
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发表时间：
2006-08-15
影响因子：
3
通讯作者：
Choubey, Jyoti
中科院分区：
文献类型：
--
作者：
Bajpai, A. K.;Choubey, Jyoti
采用单W/O乳液法制备了A型明胶纳米粒，并通过红外光谱、扫描电镜和粒度分析对其进行了表征。红外光谱清楚地证实了负载的纳米颗粒中存在明胶和阿糖胞苷，而扫描电子显微镜（SEM）图像描绘了光滑的表面、球形形状和不均匀的纳米颗粒尺寸（100-300 nm）。所制备的纳米颗粒与阿糖胞苷，一个众所周知的抗癌药物，和包埋药物的释放动力学进行了研究，作为各种实验因素的函数，如药物的载量百分比，纳米载体的化学结构，和pH值，温度，离子强度，和释放介质的性质。利用纳米粒子的聚集性，通过光学显微镜方法研究了纳米粒子的吸水性能。利用Ficks幂律对药物释放过程进行了动力学分析，并建立了药物释放量与纳米粒溶胀度之间的相关性。(c)2006 Wiley Periodicals，Inc.
Gelatin (Type A) nanoparticles were prepared by a single W/O emulsion technique and characterized by infrared (IR) spectra, scanning electron microscopy (SEM), and particle size analysis. The IR spectra clearly confirmed the presence of gelatin and cytarabine in the loaded nanoparticles while the scanning electron micrograph (SEM) image depicts smooth surface, spherical shape and uneven size of nanoparticles (100-300 nm). The prepared nanoparticles were loaded with cytarabine, a well-known anticancer drug, and the release dynamics of entrapped drug was investigated as a function of various experimental factors, such as percent loading of the drug, chemical architecture of the nanocarriers, and pH, temperature, ionic strength, and nature of the release medium. The nanoparticles were also studied for their water sorption capacity by optical microscopic method taking advantage of the aggregation of nanoparticles. The drug release process was analyzed kinetically using Ficks power law, and a correlation was established between the quantity of released drug and swelling of the nanoparticles. (c) 2006 Wiley Periodicals, Inc.