Regulation of mitochondrial gene expression in Trypanosoma brucei.
Regulation of mitochondrial gene expression in Trypanosoma brucei.
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布氏锥虫线粒体基因表达的调节。
DOI：
10.1002/bies.950060408
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Stuart,KD
中科院分区：
文献类型：
--
作者：
Stuart,KD
布氏锥虫含有功能未知的不寻常的小环状 DNA。它们与长信息 DNA 序列相连，其中包含与其他线粒体中发现的基因同源的基因。尽管这些基因在整个生命周期中进行转录，但生命周期中线粒体呼吸系统的差异产生伴随着特定转录物的丰度差异和线粒体基因转录物的差异多腺苷酸化。大多数线粒体基因都存在多个转录本。脱辅细胞色素b基因的转录物在其5'端具有线粒体DNA中不存在的核苷酸序列，在呼吸系统表达的生命周期阶段被发现。这些结果表明，在 T 生命周期中存在调节线粒体基因表达的转录后机制。布鲁塞伊。
Trypanosoma bruceimitochondria contain unusual small circular DNAs of unknown function. These are catenated with a long informational DNA sequence containing genes homologous to those found in other mitochondria. Although these genes are transcribed throughout the life cycle, differential production of the mitochondrial respiratory system during the life cycle is accompanied by differential abundance of specific transcripts and differential polyadenylation of mitochondrial gene transcripts. Multiple transcripts occur for most of the mitochondrial genes. Transcripts of the apocytochromebgene possessing nucleotide sequences at their 5′ ends which are not present in mitochondrial DNA are found at stages of the life cycle when the respiratory system is expressed. These results suggest the presence of post‐transcriptional mechanisms that regulate the expression of mitochondrial genes during the life cycle ofT. brucei.