Plasma disposition kinetics of albendazole metabolites in pigs fed different diets
Plasma disposition kinetics of albendazole metabolites in pigs fed different diets
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DOI：
10.1016/s0034-5288(96)90010-7
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发表时间：
1996-03-01
影响因子：
2.4
通讯作者：
Lanusse, CE
中科院分区：
文献类型：
--
作者：
Alvarez, LI;Saumell, CA;Lanusse, CE
研究了日粮对阿苯达唑（ABZ）及其代谢产物在猪体内代谢动力学的影响。以10 mg kg（-1）的剂量对饲喂商业生产的35%蛋白质/谷物浓缩物饲料（浓缩物组）、补充玉米谷物的乳清饲料（乳清/谷物组）或在牧场上放牧的猪（牧场组）口服ABZ。连续采集血样96小时，通过高效液相色谱法（HPLC）分析血浆中的ABZ、ABZ亚砜（ABZSO）、ABZ砜（ABZSO（2））和氨基-ABZSO（2）（NH（2）ABZSO（2））。给药后任何时间血浆中均未检测到ABZ，所有实验动物给药后0.5至30 - 48小时内检测到的主要代谢产物为ABZSO和ABZSO（2）。在ABZ给药后18 - 36小时，在所有猪组的血浆中均发现低浓度的NH（2）ABZSO（2）代谢物。ABZ代谢物在饲喂浓缩物或乳清/浓缩物饲料的猪中的药代动力学行为与在牧场放牧的猪中观察到的明显不同。ABZSO和ABZSO（2）的峰浓度（C-max）和药时曲线下面积（AUC）显著高于对照组（P
The influence of diet on the disposition kinetics of albendazole (ABZ) and its metabolites in pigs was investigated. ABZ was administered orally at 10 mg kg(-1) to pigs fed either a commercially produced 35 per cent protein/grain concentrate diet (concentrate group), a whey-based diet supplemented with corn grain (whey/grain group) or grazed on pasture (pasture group). Blood samples were taken serially for 96 hours and plasma was analysed by high performance liquid chromatography (HPLC) for ABZ, ABZ sulphoxide (ABZSO), ABZ sulphone (ABZSO(2)) and amino-ABZSO(2) (NH(2)ABZSO(2)). ABZ was not detected in plasma at any time after the treatment, and ABZSO and ABZSO(2) were the main metabolites detected between 0.5 and 30 to 48 hours after treatment in all the experimental animals. Low concentrations of the NH(2)ABZSO(2) metabolite were found in plasma between 18 and 36 hours after the administration of ABZ to all the groups of pigs. The pharmacokinetic behaviour of the ABZ metabolites in pigs fed either the concentrate or the whey/concentrate diet was substantially different from that observed in pigs grazing on pasture. The peak concentration (C-max) and areas under the concentration-time curves (AUG) for ABZSO and ABZSO(2) were significantly higher (P