Automated annotation of microbial proteomes in SWISS-PROT
Automated annotation of microbial proteomes in SWISS-PROT
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DOI：
10.1016/s1476-9271(02)00094-4
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发表时间：
2003-02-01
影响因子：
3.1
通讯作者：
Bairoch, A
中科院分区：
文献类型：
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作者：
Gattiker, A;Michoud, K;Bairoch, A
原核生物基因组的大规模测序需要自动化某些注释任务，目前在SWISS-PROT蛋白质知识库的生产中手工执行。HAMAP项目，即“微生物蛋白质组的高质量自动和手动注释”，旨在整合手动和自动注释方法，以提高管理过程的速度，同时保持数据库注释的质量。自动注释仅应用于属于手动定义的同源族的条目和没有可识别的相似性（ORFans）的条目。强制执行许多检查是为了防止错误注释的传播，并发现有问题的情况，这些情况将被引导到手动管理。该注释的结果集成在SWISS-PROT中，并提供了一个网站http://www.expasy.org/ sport /hamap/。(C) 2002 Elsevier Science Ltd.版权所有。
Large-scale sequencing of prokaryotic genomes demands the automation of certain annotation tasks currently manually performed in the production of the SWISS-PROT protein knowledgebase. The HAMAP project, or 'High-quality Automated and Manual Annotation of microbial Proteomes', aims to integrate manual and automatic annotation methods in order to enhance the speed of the curation process while preserving the quality of the database annotation. Automatic annotation is only applied to entries that belong to manually defined orthologous families and to entries with no identifiable similarities (ORFans). Many checks are enforced in order to prevent the propagation of wrong annotation and to spot problematic cases, which are channelled to manual curation. The results of this annotation are integrated in SWISS-PROT, and a website is provided at http://www.expasy.org/ sprot/hamap/. (C) 2002 Elsevier Science Ltd. All rights reserved.