Sexual differences in the control of energy homeostasis.
Sexual differences in the control of energy homeostasis.
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DOI：
10.1016/j.yfrne.2009.03.004
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发表时间：
2009-08
影响因子：
7.4
通讯作者：
Clegg DJ
中科院分区：
文献类型：
--
作者：
Shi H;Seeley RJ;Clegg DJ
肥胖的流行已经达到流行病的比例，在人类生命和医疗保健花费巨大的成本。绝经前女性与肥胖相关的代谢紊乱比男性低得多；然而，在女性绝经后，这种情况急剧增加。与肥胖相关的健康风险因脂肪组织的位置而异。分布在腹部内脏的脂肪组织比分布在皮下的脂肪组织有更大的代谢紊乱风险。区域脂肪分布存在明显的性别差异，女性的皮下脂肪更多，而男性的内脏脂肪更多。男性和女性在调节能量稳态方面存在差异。外周肥胖激素如瘦素和胰岛素以及性激素直接影响能量平衡。能量平衡、体脂分布中的两性异形以及性激素在调节这些差异中的作用是本综述的重点。
The prevalence of obesity has reached epidemic proportion with enormous costs in both human lives and healthcare dollars spent. Obesity-related metabolic disorders are much lower in premenopausal women than men; however, there is a dramatic increase following menopause in women. The health risks associated with obesity vary depending on the location of adipose tissue. Adipose tissue distributed in the abdominal visceral carry a much greater risk for metabolic disorders than does adipose tissue distributed subcutaneously. There are distinct sex-dependent differences in the regional fat distribution, women carry more fat subcutaneously whereas men carry more fat viscerally. Males and females differ with respect to their regulation of energy homeostasis. Peripheral adiposity hormones such as leptin and insulin as well as sex hormones directly influence energy balance. Sexual dimorphisms in energy balance, body fat distribution, and the role sex hormones have in mediating these differences are the focus of this review.