Unprecedented Quassinoids from Eurycoma longifolia: Biogenetic Evidence and Antifeedant Effects
Unprecedented Quassinoids from Eurycoma longifolia: Biogenetic Evidence and Antifeedant Effects
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东革阿里中前所未有的苦木素：生物遗传学证据和拒食作用
DOI：
10.1021/acs.jnatprod.0c00244
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发表时间：
2020-05-22
影响因子：
5.1
通讯作者：
Wang, Ying
中科院分区：
文献类型：
--
作者：
Yang, Wei-Qun;Shao, Xue-Hua;Wang, Ying
从长叶Eurycoma longifolia的根中分离到6个新的准类群（1 ~ 6），通过光谱分析和单晶x射线晶体学实验确定了它们的绝对构型。化合物1和2是一类具有不寻常的碳-26碳骨架的新类星体的首批成员。化合物6具有C-20笼状支架，具有前所未有的密集功能化2,5-二氧杂环[5.2.2.0(4,8)]十一烷核心。这两个C-26类类星体1和2的发现为更好地理解C-30三萜前体到类星体的生物发生过程提供了有力的证据。化合物5对小菜蛾（diamondback moth， DBM）幼虫具有显著的拒食活性，并具有良好的系统吸收和积累特性。
Six new quassinoids (1-6) were isolated from the roots of Eurycoma longifolia, and their structures with absolute configurations were determined unambiguously by spectroscopic analyses and single-crystal X-ray crystallographic experiments. Compounds 1 and 2 are the first members of a new class of quassinoids with an unusual C-26 carbon skeleton. Compound 6 features a C-20 cage-like scaffold with an unprecedented densely functionalized 2,5-dioxatricyclo[5.2.2.0(4,8)]undecane core. The discovery of the two C-26 quassinoids 1 and 2 has provided firm evidence for the better understanding the biogenetic process from C-30 triterpenoid precursors to quassinoids. Compound 5 exhibited significant antifeedant activity on the diamondback moth (DBM) larvae and excellent systemic absorption and accumulated properties in Brassica chinensis.