Iron Catalyzed Highly Enantioselective Epoxidation of Cyclic Aliphatic Enones with Aqueous H2O2
Iron Catalyzed Highly Enantioselective Epoxidation of Cyclic Aliphatic Enones with Aqueous H2O2
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DOI：
10.1021/jacs.5b12681
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发表时间：
2016-03-02
影响因子：
15
通讯作者：
Costas, Miguel
中科院分区：
文献类型：
--
作者：
Cusso, Olaf;Cianfanelli, Marco;Costas, Miguel
一种具有C-1-对称四齿N-基配体的铁配合物催化环烯酮和环己烯酮与过氧化氢水溶液的不对称环氧化反应，在温和的条件下和短的反应时间内以良好至优异的产率和对映选择性（高达99%产率和95%ee）提供相应的环氧化物。提供的证据表明，反应涉及的亲电氧化剂，和这个元素是采用在进行现场选择性环氧化的烯酮含有两个烯烃网站。
An iron complex with a C-1-symmetric tetra dentate N-based ligand catalyzes the asymmetric epoxidation of cyclic enones and cyclohexene ketones with aqueous hydrogen peroxide, providing the corresponding epoxides in good to excellent yields and enantioselectivities (up to 99% yield, and 95% ee), under mild conditions and in short reaction times. Evidence is provided that reactions involve an electrophilic oxidant, and this element is employed in performing site selective epoxidation of enones containing two alkene sites.