Soluble biomarkers and morbidity and mortality among people infected with HIV: summary of published reports from 1997 to 2010.
Soluble biomarkers and morbidity and mortality among people infected with HIV: summary of published reports from 1997 to 2010.
复制标题
感染艾滋病毒的人的可溶性生物标志物以及发病率和死亡率：1997年至2010年发表的报告摘要。
DOI：
10.1097/coh.0b013e32833ed75d
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发表时间：
2010-11
影响因子：
4.1
通讯作者：
Emery S
中科院分区：
文献类型：
--
作者：
Neaton JD;Neuhaus J;Emery S
确定了 1997 年至 2010 年 5 月发表的文章，这些文章报告了可溶性生物标志物与 HIV 感染者临床结果之间关系的研究结果，并总结了检查生物标志物预测临床结果的增量值（相对于 CD4+ 计数和 HIV RNA 水平）的研究。 MEDLINE 数据库中发现了 1,500 多篇符合选定 MeSH 术语的文章。三十八人符合纳入审查的标准。其中 15 篇文章自 2008 年以来发表。大多数文章评估了反映炎症和免疫激活的生物标志物。 25 项研究评估了生物标志物与全因死亡率之间的关系。存储的样本用于许多研究，以及那些通常不关注作为常规护理一部分进行测量的生物标志物的研究。其中八份报告采用了病例对照设计，其中大部分都嵌套在队列研究或临床试验中。建立生物标志物与临床结果之间的关系是生物标志物评估的重要一步。为了推进与艾滋病毒感染者相关的生物标志物的研究，需要进行长期随访的大型研究、仔细记录的临床事件和样本库。
Published articles from 1997 through May 2010 that reported findings on the relationship of soluble biomarkers with clinical outcomes among people infected with HIV were identified, and studies that examined the incremental value (over that of CD4+ count and HIV RNA level) that biomarkers had for predicting clinical outcomes were summarized. Over 1,500 articles were identified on MEDLINE databases that met selected MeSH terms. Thirty-eight met criteria for inclusion in the review. Fifteen of the articles were published since 2008. Most evaluated biomarkers reflecting inflammation and immune activation. For 25 studies, the relationship between the biomarker and all-cause mortality was evaluated. Stored samples were used for many studies, and those that did not usually focused on biomarkers that are measured as part of routine care. Eight of the reports utilized a case-control design and most of these were nested within a cohort study or a clinical trial. Establishing the relationship between a biomarker and a clinical outcome is an important step in biomarker evaluation. To advance research on biomarkers relevant to people with HIV, large studies with long follow-up, carefully documented clinical events, and specimen repositories will be needed.