Effects of interaction of NOS1AP gene polymorphisms and childhood abuse on paranoid personality disorder features among male violent offenders in China
Effects of interaction of NOS1AP gene polymorphisms and childhood abuse on paranoid personality disorder features among male violent offenders in China
复制标题
NOS1AP基因多态性与儿童期虐待的交互作用对中国男性暴力犯罪者偏执型人格障碍特征的影响
DOI：
10.1016/j.jpsychires.2020.07.026
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发表时间：
2020
影响因子：
4.8
通讯作者：
Zhang Ning
中科院分区：
文献类型：
--
作者：
Wang Qiuyu;Liu Gang;Li Jinyang;Zhang Min;Chen Haocheng;Chen Chen;Wang Chun;Liu Na;Zhang Ning
背景：偏执型人格障碍（PPD）是遗传和环境因素复杂协同作用的结果。童年受虐是其中一个风险因素。一氧化氮合酶1适配蛋白（NOS1AP）是精神分裂症的候选基因，其病理生理机制与PPD相似。本研究探讨了NOS1AP基因多态性和童年虐待史在预测中国汉族男性暴力犯罪者PPD特征中的作用。方法：对423名男性囚犯的NOS1AP单核苷酸多态性rs4145621、rs3751284、rs348624和rs6680461进行基因分型。参与者评估包括人口统计信息、儿童虐待测量（儿童创伤问卷，CTQ）和PPD特征（人格诊断问卷-4，PDQ-4）。通过PDQ-4量表将参与者分为PPD组和非PPD组。结果：回归分析显示，情绪虐待、NOS1AP snp rs348624和rs4145621对监狱样本PPD特征有预测作用（P < 0.05）。儿童虐待史与NOS1AP snp rs3751284和rs6680461之间存在显著的相互作用。携带rs3751284 C等位基因的个体在暴露于较高水平的情绪忽视时易患PPD特征（P < 0.05）；携带rs6680461 G等位基因的个体在遭受较高程度的精神虐待、身体虐待和性虐待时更易出现PPD特征（P < 0.01）。结论：这些结果表明，童年虐待与NOS1AP基因多态性之间的相互作用可能影响PPD的特征，至少在男性暴力犯罪者中是如此。
Background: Paranoid Personality Disorder (PPD) results from a complex synergy between genetic and environmental factors. Childhood abuse is one of risk factors. Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) is a candidate gene of schizophrenia, which has similar pathophysiology to PPD. This study investigated the role of NOS1AP gene polymorphisms and a history of childhood abuse in predicting PPD features among male violent offenders in the Chinese Han population. Method: Four NOS1AP Single Nucleotide Polymorphisms (SNPs), rs4145621, rs3751284, rs348624 and rs6680461 were genotyped in a sample of 423 male prisoners. Participant evaluations included demographic information, measures of childhood abuse (Child Trauma Questionnaire, CTQ), and PPD features (Personality Diagnostic Questionnaire-4, PDQ-4). Participants were divided into a PPD group and non-PPD group assessed by PDQ-4. Results: Regression analysis revealed that emotional abuse, NOS1AP SNPs rs348624 and rs4145621 predicted PPD features (P < 0.05) among prison samples. Significant interactions between childhood abuse history and NOS1AP SNPs rs3751284 and rs6680461 were also observed. Individuals carrying the C allele of rs3751284 were susceptible to PPD features when exposed to higher levels of emotional neglect (P < 0.05); Individuals with the G allele of rs6680461 were susceptible to PPD features when exposed to higher levels of emotional, physical and sexual abuse (P < 0.01). Conclusions: These results suggest that the interaction between childhood abuse and NOS1AP gene polymorphisms may have an influence on PPD features, at least in male violent offenders.