Immunohistochemical detection of steroid receptors in breast cancer: a working protocol
Immunohistochemical detection of steroid receptors in breast cancer: a working protocol
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DOI：
10.1136/jcp.53.8.634
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发表时间：
2000-08-01
影响因子：
3.4
通讯作者：
Walker, R
中科院分区：
文献类型：
--
作者：
Leake, R;Barnes, D;Walker, R
雌激素受体的生化测定显示了了解组织内受体浓度的临床价值。免疫组织化学检测正在迅速取代生化检测。因此，至关重要的是要有一个等效的评分系统，将具有相同的预测值。本文报告了一个实用的协议和评分系统，应实现这一目标。这种方法应该适用于免疫组织化学检测的更多生物标志物。
The biochemical assay for the oestrogen receptor has shown the clinical value of knowing the concentration of the receptor within tissue. The immunohistochemical assay is rapidly taking over from the biochemical assay. Therefore, it is vital to have an equivalent scoring system that will have the same predictive value. This paper reports both a practical protocol and a scoring system that should achieve this aim. This approach should be applicable to many more biomarkers detected by immunohistochemistry.