FDG PET imaging in hereditary thyroid cancer
FDG PET imaging in hereditary thyroid cancer
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DOI：
10.1016/s0748-7983(03)00137-9
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发表时间：
2003-12-01
期刊：
影响因子：
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通讯作者：
Ésik, O
中科院分区：
文献类型：
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作者：
Boér, A;Szakall, S;Ésik, O
目的：报告不同影像学方法在多发性内分泌瘤2A（MEN 2A）或家族性甲状腺髓样癌（FMTC）患者分期中的作用。材料和方法：对14例新诊断的基因携带者进行了颈部超声（US）、颈部和纵隔CT、MRI、全身[131 I]碘苄胍（MIBG）造影和[F-18]氟脱氧葡萄糖（FDG）PET扫描。CT和MRI仅定位直径≥ 5 mm的肿瘤。MIBG甲状腺造影和FDG PET不能识别甲状腺内的MTC病灶。全身FDG PET确定了两个真阳性和一个假阳性淋巴结转移。MIBG淋巴结造影未发现淋巴结转移。全甲状腺切除术进行了12例，次全甲状腺切除术在两个subject.Conclusions：全身FDG PET和颈部US帮助阶段携带突变基因验证MEN 2A或FMTC的个人。(C)2003 Elsevier Ltd.保留所有权利。
Aim: To report the role of different imaging methods in staging individuals with multiple endocrine neoplasia 2A (MEN2A) or familial medullary thyroid carcinoma (FMTC). Material and methods: Fourteen newly diagnosed gene carriers underwent cervical ultrasound scanning (US), cervical and mediastinal CT, MRI and whole-body meta-[(131) I]iodobenzylguanidine (MIBG) scintigraphy and [F-18]fluorodeoxyglucose (FDG) PET scanning.Results: US identified seven true primary cancer. CT and MRI located only tumors greater than or equal to5 mm in diameter. MIBG scintigraphy and FDG PET could not identify MTC foci within the thyroid. Whole-body FDG PET identified two true-positive and one false-positive lymph node metastases. MIBG scintigraphy did not identify lymph node metastases. Total thyroidectomy was performed in 12 cases, and subtotal thyroidectomy in two subjects.Conclusions: Whole-body FDG PET and cervical US help stage individuals carrying mutant genes verifying MEN2A or FMTC. (C) 2003 Elsevier Ltd. All rights reserved.