INHIBITION OF CALCIUM HYDROXYAPATITE CRYSTAL GROWTH BY POLYPHOSPHONATES AND POLYPHOSPHATES
INHIBITION OF CALCIUM HYDROXYAPATITE CRYSTAL GROWTH BY POLYPHOSPHONATES AND POLYPHOSPHATES
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DOI：
10.1007/bf02058658
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发表时间：
1969-01-01
期刊：
影响因子：
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通讯作者：
FRANCIS, MD
中科院分区：
文献类型：
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作者：
FRANCIS, MD
本文研究了由钙离子和磷酸根离子溶液形成结晶羟基磷灰石钙的过程以及多膦酸盐和多磷酸盐对羟基磷灰石钙晶体生长的抑制作用。聚膦酸盐，乙烷-1-羟基-1，1-二膦酸二钠和二氯甲烷二膦酸二钠，是羟基磷灰石钙晶体生长的有效抑制剂。只要系统中存在所需水平的完整多磷酸盐，多磷酸盐也是羟磷灰石钙晶体生长的有效抑制剂。然而，由于它们的水解不稳定性，这是由高温，低pH值，和某些酶增强，聚磷酸盐的浓度随时间在体外降低，其作为抑制剂的活性丧失。与多磷酸盐相比，多膦酸盐是水解稳定的。聚膦酸酯化学吸附在羟基磷灰石钙微晶的表面上，并以其它已知的晶体生长毒物的方式，从而防止进一步的晶体生长。聚膦酸酯的稳定性及其在磷灰石上的化学吸附表明其在涉及病理性钙和磷酸盐代谢的医学和牙科应用中的用途。
The formation of crystalline calcium hydroxyapatite from solutions of calcium and phosphate ions and the inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and polyphosphates have been studied. The polyphosphonates, disodium ethane-1-hydroxy-1,1-diphosphonate and disodium dichloromethane diphosphonate, are effective inhibitors of calcium hydroxyapatite crystal growth. The polyphosphates are also effective inhibitors of calcium hydroxyapatite crystal growth as long as the required level of intact polyphosphate is present in the system. However, because of their hydrolytic instability, which is enhanced by high temperature, low pH, and certain enzymes, the concentration of the polyphosphate decreases with timein vitro, and its activity as an inhibitor is lost. In contrast to the polyphosphates, the polyphosphonates are hydrolytically stable. The polyphosphonates are chemisorbed on the surface of the microcrystallites of calcium hydroxyapatite and, in the manner of other known crystal growth poisons, thus prevent further crystal growth. The stability of the polyphosphonates and their chemisorption on apatite suggest their use in medical and dental applications involving pathological calcium and phosphate metabolism.