Prefrontal cortex modulates placebo analgesia
Prefrontal cortex modulates placebo analgesia
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DOI：
10.1016/j.pain.2009.09.033
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发表时间：
2010-03-01
期刊：
影响因子：
7.4
通讯作者：
Schoenbaechler, Georg
中科院分区：
文献类型：
--
作者：
Krummenacher, Peter;Candia, Victor;Schoenbaechler, Georg
期望和信念调节疼痛的体验，这在安慰剂镇痛中尤其明显。背外侧前额叶皮层（DLPFC）与疼痛调节以及认知表征的产生、维持和操纵相关，这与其在预期中的作用一致。在热痛范例中，我们采用非侵入性低频重复经颅磁刺激（rTMS）暂时破坏左右DLPFC功能，或使用TMS设备本身作为安慰剂，然后应用预期诱导的安慰剂镇痛。结果表明，安慰剂显著增加痛阈和疼痛耐受性。虽然rTMS不影响疼痛体验，但它完全阻断了安慰剂镇痛。这些发现表明，预期诱导的安慰剂镇痛是由对称的前额叶皮层功能介导的。(c)2009年国际疼痛研究协会。由Elsevier B出版。V.保留所有权利。
Expectations and beliefs modulate the experience of pain, which is particularly evident in placebo analgesia. The dorsolateral prefrontal cortex (DLPFC) has been associated with pain regulation and with the generation, maintenance and manipulation of cognitive representations, consistent with its role in expectation. In a heat-pain paradigm, we employed non-invasive low-frequency repetitive transcranial magnetic stimulation (rTMS) to transiently disrupt left and right DLPFC function or used the TMS device itself as a placebo, before applying an expectation-induced placebo analgesia. The results demonstrated that placebo significantly increased pain threshold and pain tolerance. While rTMS did not affect pain experience, it completely blocked placebo analgesia. These findings suggest that expectation-induced placebo analgesia is mediated by symmetric prefrontal cortex function. (c) 2009 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved.