Boronated Porphyrins and Chlorins as Potential Anticancer Drugs
Boronated Porphyrins and Chlorins as Potential Anticancer Drugs
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硼化卟啉和二氢卟酚作为潜在的抗癌药物
DOI：
10.5012/bkcs.2007.28.11.1910
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发表时间：
2007
影响因子：
1.7
通讯作者：
V. Kalinin
中科院分区：
文献类型：
--
作者：
V. Ol’shevskaya;A. Zaytsev;A. N. Savchenko;A. Shtil;C. Cheong;V. Kalinin
分析了合成及天然卟啉和二氢卟吩的新型硼化共轭物设计的最新进展。这些化合物作为培养肿瘤细胞的细胞毒剂以及肿瘤异种移植物光动力治疗中的光毒素显示出高效能。因此，硼化卟啉和二氢卟吩作为一类有前景的抗癌药物出现，具有潜在的多重优势：在单一治疗中作为化学治疗药物，在联合治疗中作为光增敏剂和放射增敏剂。
Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.
影响因子：
2.8
作者：
Renner, M. W.;Miura, M.;Vicente, M. G. H.
通讯作者：
Vicente, M. G. H.