Responses to Malarial Antigens Are Altered in Helminth-Infected Children
Responses to Malarial Antigens Are Altered in Helminth-Infected Children
复制标题
DOI：
10.1086/598687
复制
发表时间：
2009-05-15
影响因子：
6.4
通讯作者：
Yazdanbakhsh, Maria
中科院分区：
文献类型：
--
作者：
Hartgers, Franca C.;Obeng, Benedicta B.;Yazdanbakhsh, Maria
疟疾和寄生虫感染常常在同一热带地区同时发生。关于人类寄生虫和疟疾合并感染后果的研究很少，而且主要是流行病学方面的研究，关于细胞免疫反应的信息很少。在这项研究中，我们调查了生活在加纳农村地区的儿童的抗疟疾免疫反应，该地区的寄生虫感染和恶性疟原虫感染都很高。用感染恶性疟原虫的红细胞（irbc）培养全血标本，测定促炎性和抗炎性细胞因子及免疫调节分子。在对irbc的反应中，来自蠕虫感染儿童的样本中白细胞介素(IL)-10的水平高于未感染儿童的样本，细胞因子信号传导抑制因子(SOCS)-3、Foxp3和程序性死亡(PD)-1的表达也高于未感染儿童。此外，SOCS-3基因的表达与IL-10的产生有显著的相关性。这些结果表明，蠕虫感染的存在调节了对疟疾寄生虫的免疫反应，使其更具抗炎作用。
Malaria and helminth infections often coincide in the same tropical regions. Studies of the consequences of helminth and malaria coinfection in humans have been few and are mainly epidemiological, with little information on cellular immune responses. In this study, we investigated the antimalarial immune responses of Ghanaian children living in a rural area with a high prevalence of both helminth infection and Plasmodium falciparum infection. Whole blood specimens were cultured with P. falciparum-infected red blood cells (iRBCs), and pro- and anti-inflammatory cytokines and immune regulatory molecules were measured. In response to iRBCs, levels of interleukin (IL)-10, but not tumor necrosis factor-alpha, were higher in samples from helminth-infected children than in those from uninfected children, as was expression of the regulatory molecules suppressor of cytokine signaling (SOCS)-3, Foxp3, and programmed death (PD)-1. Furthermore, a significant correlation was found between SOCS-3 gene expression and IL-10 production. These results indicate that the presence of helminth infection modulates the immune response to malarial parasites, making it more anti-inflammatory.