Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation
Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation
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DOI：
10.1161/01.atv.0000078603.90302.4a
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发表时间：
2003-07-01
影响因子：
8.7
通讯作者：
Vita, JA
中科院分区：
文献类型：
--
作者：
Amar, S;Gokce, N;Vita, JA
本研究的目的是确定牙周病是否与内皮功能障碍和全身炎症有关。流行病学研究表明，严重的牙周病与心血管疾病的风险增加，但机制仍然unknown.Methods和Results-We评估流量介导的扩张和硝酸甘油介导的扩张肱动脉血管超声在26例晚期牙周病和29名对照组。年龄和性别匹配的组，并排除高胆固醇血症，糖尿病，高血压和吸烟史的患者。我们还检查了C-反应蛋白的血清水平，使用一个既定的高灵敏度的方法。与对照组相比，晚期牙周病患者的血流介导的扩张较低（7.8 ± 4.6% vs 11.75.3%，P=0.005）。硝酸甘油介导的扩张在两组中相当。与健康对照组相比，晚期牙周炎患者血清中高敏C反应蛋白水平较高（2.3+/-2.3vs1.0 +/-1.0mg/L，P=0.03）。结论：晚期牙周病患者表现出内皮功能障碍和全身炎症的迹象，这可能增加了他们患心血管疾病的风险。
Objective-The purpose of this study was to determine whether periodontal disease is associated with endothelial dysfunction and systemic inflammation. Epidemiological studies suggest that severe periodontal disease is associated with increased cardiovascular disease risk, but the mechanisms remain unknown.Methods and Results-We assessed flow-mediated dilation and nitroglycerin-mediated dilation of the brachial artery using vascular ultrasound in 26 subjects with advanced periodontal disease and 29 control subjects. The groups were matched for age and sex, and patients with hypercholesterolemia, diabetes mellitus, hypertension, and history of cigarette smoking were excluded. We also examined serum levels of C-reactive protein using an established high-sensitivity method. Subjects with advanced periodontal disease had lower flow-mediated dilation compared with control patients (7.8+/-4.6% versus 11.75.3%, P=0.005). Nitroglycerin-mediated dilation was equivalent in the two groups. Subjects with advanced periodontitis exhibited higher serum levels of high-sensitivity C-reactive protein compared with healthy controls patients (2.3+/-2.3 versus 1.0+/-1.0 mg/L, P=0.03).Conclusions-Subjects with advanced periodontal disease exhibit endothelial dysfunction and evidence of systemic inflammation, possibly placing them at increased risk for cardiovascular disease.