Dyskinesia after fetal cell transplantation for parkinsonism: A PET study
Dyskinesia after fetal cell transplantation for parkinsonism: A PET study
复制标题
DOI：
10.1002/ana.10359
复制
发表时间：
2002-11-01
影响因子：
11.2
通讯作者：
Eidelberg, D
中科院分区：
文献类型：
--
作者：
Ma, YL;Feigin, A;Eidelberg, D
多巴胺细胞植入治疗帕金森氏病后，在缺乏或仅使用少量多巴胺能药物的情况下出现持续性运动障碍。在本研究中，我们使用[F-18]氟多巴（FDOPA）和正电子发射断层扫描来确定这种并发症是否由移植后多巴胺功能的特异性改变引起。将这些患者（DYS+, n = 5）的尾状核和壳核FDOPA摄取值与年龄和疾病持续时间匹配的未发生该并发症的移植受者队列（DYS-, n = 12）进行比较。两组的PET信号在基线和移植后12个月和24个月进行比较。我们发现DYS+移植受者壳核FDOPA摄取显著增加（p < 0.005）。这些增加主要局限于左壳核内的两个区域。除了嗅觉后区FDOPA摄取在基线时显著减少外，DYS+组也显示腹侧相对增加，其中术前多巴胺能输入相对保留。术后24个月随访期间，FDOPA摄取未达到异常值。这些发现表明，多巴胺能功能的不平衡增加可能使帕金森病神经元移植的结果复杂化。
Persistent dyskinesias in the absence of or with only minimal amounts of dopaminergic medication have been reported after dopamine cell implantation for Parkinson's disease. In this study, we used [F-18]fluorodopa (FDOPA) and positron emission tomography to determine whether this complication resulted from specific alterations in dopamine function after transplantation. Caudate and putamen FDOPA uptake values in these patients (DYS+, n = 5) were compared with those obtained in a cohort of age- and disease duration-matched transplant recipients who did not develop this complication (DYS-, n = 12). PET signal for both groups was compared at baseline and at 12 and 24 months after transplantation. We found that putamen FDOPA uptake was significantly increased (p < 0.005) in DYS+ transplant recipients. These increases were predominantly localized to two zones within the left putamen. In addition to the posterodorsal zone in which a prominent reduction in FDOPA uptake was present at baseline, the DYS+ group also displayed a relative increase ventrally, in which preoperative dopaminergic input was relatively preserved. Postoperative FDOPA uptake did not reach supranormal values over the 24-month follow-up period. These findings suggest that unbalanced increases in dopaminergic function can complicate the outcome of neuronal transplantation for Parkinsonism.