Lineage switch from lymphoma to myeloid neoplasms: First case series from a single institution.
Lineage switch from lymphoma to myeloid neoplasms: First case series from a single institution.
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谱系从淋巴瘤转变为髓样肿瘤：单个机构的第一个病例系列。
DOI：
10.1515/med-2022-0521
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发表时间：
2022
期刊：
影响因子：
2.1
通讯作者：
Nie, Danian
中科院分区：
文献类型：
--
作者：
Yang, Wenjuan;Xie, Shuangfeng;Li, Yiqing;Wang, Jieyu;Xiao, Jie;Huang, Kezhi;Wang, Xiuju;Wu, Yudan;Ma, Liping;Nie, Danian
淋巴瘤复发在临床上很常见，但复发时的谱系转换却很少见。虽然一些病例报告急性淋巴细胞白血病（ALL）在复发时转变为急性髓细胞白血病（AML）或髓样肉瘤，但表型转变很少发生在其他类型的淋巴瘤中。在这里，我们报告6例谱系转换从淋巴瘤骨髓肿瘤。在我们的队列中，3例为套细胞淋巴瘤（MCL），另外3例为T细胞淋巴母细胞淋巴瘤（T-LBL）、B细胞淋巴母细胞淋巴瘤（B-LBL）和弥漫性大B细胞淋巴瘤（DLBCL）。发生家系转换时，大多数为AML M5表型，仅1例为骨髓增生异常综合征（MDS）表型。11 q23/混合系白血病（MLL）重排均为阴性。虽然强化治疗和干细胞移植已被应用于大多数情况下，不良的结果无法逆转。因此，我们发现，谱系转换不仅可以发生从ALL到AML或反之亦然，而且可以发生从MCL或DLBCL到AML。此外，与儿科患者相比，成人恶性血液病中谱系转换中MLL重排的发生率较低。
Lymphoma relapse is very common in clinical work, but lineage switch at relapse is rare. Although some cases have reported acute lymphocytic leukemia (ALL) switch to acute myeloid leukemia (AML) or myeloid sarcoma upon relapse, phenotype switch seldom occurs in other types of lymphoma. Here we report six cases with lineage switch from lymphoma to myeloid neoplasms. In our cohort, three cases were mantle cell lymphoma (MCL), and the other three cases were T-cell lymphoblastic lymphoma (T-LBL), B-cell lymphoblastic lymphoma (B-LBL), and diffuse large B-cell lymphoma (DLBCL) at the initial diagnosis. When linage switch occurred, most cases were AML M5 phenotypes, and only one case was myelodysplastic syndrome (MDS) phenotype. 11q23/mixed-lineage leukemia (MLL) rearrangement was negative in all cases. Although intensive therapy and stem cell transplantation have been applied in most cases, the poor outcome cannot be reversed. Therefore, we found that lineage switch could occur not only from ALL to AML or vice versa, but also from MCL or DLBCL to AML. Moreover, the incidence of MLL rearrangement in lineage switch is lower in adult hematologic malignancies as compared with pediatric patients.
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影响因子：
5.9
作者：
Cirovic B;Schönheit J;Kowenz-Leutz E;Ivanovska J;Klement C;Pronina N;Bégay V;Leutz A
通讯作者：
Leutz A
影响因子：
12.8
作者：
Rossi, Jorge G.;Bernasconi, Andrea R.;Felice, Maria S.
通讯作者：
Felice, Maria S.
影响因子：
32.4
作者：
Laiosa, Catherine V.;Stadtfeld, Matthias;Graf, Thomas
通讯作者：
Graf, Thomas
DOI：
10.1111/j.1751-553x.2007.00968.x
发表时间：
2009-02-01
影响因子：
3
作者：
Shivarov, V.;Stoimenov, A.;Guenova, M.
通讯作者：
Guenova, M.
影响因子：
64.5
作者：
Hanna, Jacob;Markoulaki, Styliani;Jaenisch, Rudolf
通讯作者：
Jaenisch, Rudolf