Fusel Alcohols Regulate Translation Initiation by Inhibiting eIF2B to Reduce Ternary Complex in a Mechanism That May Involve Altering the Integrity and Dynamics of the eIF2B Body

Fusel Alcohols Regulate Translation Initiation by Inhibiting eIF2B to Reduce Ternary Complex in a Mechanism That May Involve Altering the Integrity and Dynamics of the eIF2B Body
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杂醇醇通过抑制 eIF2B 减少三元复合物来调节翻译起始,其机制可能涉及改变 eIF2B 体的完整性和动态

DOI:
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发表时间:
2010
影响因子:
3.3
通讯作者:
M. Ashe
M. Ashe
中科院分区:
生物学3区
文献类型:
--
作者:
Eleanor Taylor;S. Campbell;Christian D. Griffiths;P. Reid;John W. Slaven;Richard J Harrison;Paul F. G. Sims;G. Pavitt;D. Delneri;M. Ashe

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这项研究强调了eIF2B体和调节翻译起始之间的联系,作为酿酒酵母对应激的反应。杂醇醇参与向细胞发出氮缺乏的信号,并且它们通过阻止eIF2B体在整个细胞中的运动来抑制蛋白质合成。
This study highlights a connection between the eIF2B body and the regulation of translation initiation as a response to stress in Saccharomyces cerevisiae. Fusel alcohols are involved in signaling nitrogen scarcity to the cell and they inhibit protein synthesis by preventing the movement of the eIF2B body throughout the cell.
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