ANDROGEN INSENSITIVITY AS A CAUSE OF INFERTILITY IN OTHERWISE NORMAL MEN
ANDROGEN INSENSITIVITY AS A CAUSE OF INFERTILITY IN OTHERWISE NORMAL MEN
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DOI：
10.1056/nejm197902013000503
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
MACDONALD, PC
中科院分区：
文献类型：
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作者：
AIMAN, J;GRIFFIN, JE;MACDONALD, PC
为了确定雄激素不敏感是否会导致严重的少精子症或无精子症，对3名无血缘关系、表型正常、有长期不育史的男性进行了研究。睾酮的平均血浆浓度和生产率分别为14.3 ng/ml和10.1 mg/天，约为正常男性平均值的两倍。3例受试者中有2例血清促黄体激素浓度升高。培养的生殖器皮肤成纤维细胞的特异性高亲和力双氢睾酮结合能力为8、0和10 fmol/ml细胞蛋白，值为正常男性和女性的一半（或更少），但与睾丸女性化不完全或赖芬斯坦综合征表现为部分雄激素不敏感的受试者的值相似。低量的雄激素受体和高血清促性腺激素和血浆睾酮生成率的组合表明，这些不育男性的精子发生缺陷是雄激素不敏感的后果。
To ascertain if androgen insensitivity causes severe oligospermia or azoospermia 3 unrelated, phenotypically normal men with long histories of infertility were studied. The mean plasma concentrations and production rates of testosterone were 14.3 ng/ml and 10.1 mg per day, respectively, values approximately twice the average found in normal men. Serum luteinizing hormone concentrations were elevated in 2 of the 3 subjects. The specific high-affinity dihydrotestosterone binding capacity of cultured genital-skin fibroblasts was 8, 0 and 10 f[fento]mol/ml of cellular protein, values half (or less) of those from normal men and women but similar to values in subjects with partial androgen insensitivity manifested by incomplete testicular feminization or Reifenstein syndrome. The low amount of androgen receptor and the combination of high serum gonadotropins and plasma testosterone production rates suggest that the defective spermatogenesis in these infertile men was the consequence of androgen insensitivity.