The use of mouse models to understand and improve cognitive deficits in Down syndrome
The use of mouse models to understand and improve cognitive deficits in Down syndrome
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DOI：
10.1242/dmm.007716
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发表时间：
2011-09-01
影响因子：
4.3
通讯作者：
Reeves, Roger H.
中科院分区：
文献类型：
--
作者：
Das, Ishita;Reeves, Roger H.
近年来，通过小鼠模型对唐氏综合征（DS）个体的认知障碍的治疗取得了显着进展。在这篇综述中，我们简要描述了小鼠模型的表型，代表药物测试的结果目标，用于评估认知障碍的行为测试和已知的作用机制的几种药物，正在使用的临床前研究或可能在临床试验中进行测试。在三体脑中受这些不同药物影响的靶点分布和途径的重叠为DS研究和药物开发提供了新的途径。
Remarkable advances have been made in recent years towards therapeutics for cognitive impairment in individuals with Down syndrome (DS) by using mouse models. In this review, we briefly describe the phenotypes of mouse models that represent outcome targets for drug testing, the behavioral tests used to assess impairments in cognition and the known mechanisms of action of several drugs that are being used in preclinical studies or are likely to be tested in clinical trials. Overlaps in the distribution of targets and in the pathways that are affected by these diverse drugs in the trisomic brain suggest new avenues for DS research and drug development.