Reduced muscle strength of knee extensors is a risk factor for silent lacunar infarcts among Japanese elderly people: the Bunkyo Health Study.
Reduced muscle strength of knee extensors is a risk factor for silent lacunar infarcts among Japanese elderly people: the Bunkyo Health Study.
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文京健康研究 (Bunkyo Health Study) 指出，膝关节伸肌肌力下降是日本老年人无症状性腔隙性梗塞的危险因素。
DOI：
10.1002/crt2.24
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发表时间：
2020
影响因子：
--
通讯作者：
Watada H
中科院分区：
文献类型：
--
作者：
Someya Y;Tamura Y;Kaga H;Sugimoto D;Kadowaki S;Suzuki R;Aoki S;Hattori N;Motoi Y;Shimada K;Daida H;Ishijima M;Kaneko K;Nojiri S;Kawamori R;Watada H
BackgroundSilent lacunar infarcts (SLIs) are often incidentally diagnosed by brain magnetic resonance imaging in elderly people and are associated with the future onset of stroke, dementia, and frailty. While decreased muscle strength was reported as a risk factor for stroke, it is still unclear whether it also predisposes to SLI. In this study, we investigated the association between muscle strength and SLI in elderly subjects.MethodsThe subjects were 1536 elderly people aged 65–84 years without previous stroke events, living in an urban area of Tokyo, Japan, and recruited in the Bunkyo Health Study. Lacunar infarcts were defined by brain magnetic resonance imaging. Muscle strength of the knee extensors was measured using a dynamometer. After categorizing subjects by age and sex, we divided them into three groups based on muscle strength tertiles (High, Medium, and Low) and investigated the association between muscle strength and SLI.ResultsThe mean subject age was 73.0 ± 5.4 years, and 58.9% were female. The prevalence of SLI was 16.4% and was inversely associated with muscle strength (High, 12.3%; Medium, 17.7%; and Low, 19.3%;Pfor trend 0.003). After multivariate adjustment, the odds ratio for SLI was increased in the Medium and Low groups compared with the High group (High, 1.00 [reference]; Medium, 1.42 [95% confidence interval: 0.98–2.04]; and Low: 1.48 [1.02–2.14]), and the linear trend across the three groups was significant (Pfor trend 0.043).ConclusionsReduced knee extensor muscle strength is associated with SLI among Japanese elderly, independently of other established risk factors.
