Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patients
Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patients
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DOI：
10.2337/diacare.19.4.341
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发表时间：
1996-04-01
期刊：
影响因子：
16.2
通讯作者：
Utter, AC
中科院分区：
文献类型：
--
作者：
Kang, J;Robertson, RJ;Utter, AC
目的-这项研究的主要目的是评估急性影响运动的不同强度对血浆葡萄糖和胰岛素的反应，口服葡萄糖challenge.RESEARCH设计和方法-六个肥胖的男性和六个肥胖的男性NIDDM相似的年龄，体重，体脂百分比，和Vo（2 peak）参加了这项研究。每名受试者接受两次为期7天的运动计划，每次间隔2周。在每个7天的运动期间，受试者每天在对应于50%Vo（2 peak）70 min或70%Vo（2 peak）50 min的功率输出下骑自行车。在第7天使用[H-3]葡萄糖输注技术结合间接热量测定法估计运动期间的肌糖原利用率。在每天之前和之后的每一个7天的运动期间，3小时口服葡萄糖耐量试验（OGTT）后，12小时过夜Fast.Results -平均热量消耗没有不同的运动在50和70%Vo（2 peak）在肥胖和肥胖NIDDM受试者。然而，在这方面，碳水化合物的氧化程度较高肥胖者在70%Vo（2 peak）运动时与50%Vo（2 peak）运动时比较，差异有统计学意义（P < 0.05）（77 +/- 5 vs. 68 +/- 6 g）和肥胖NIDDM受试者（70 +/- 4 vs. 58 +/- 6 g）肥胖受试者在70% Vo（2 peak）运动时肌糖原利用率也高于50% Vo（P < 0.05）（59 +/- 9 vs. 30 +/- 7 g）和肥胖NIDDM受试者（48 +/- 5 vs. 24 +/- 5 g）。在肥胖受试者中，在50%或70% Vo（2峰）运动7天后，OGTT期间的血糖反应面积没有变化。OGTT期间的血浆胰岛素反应面积在以50%和70%Vo运动7天后也没有变化（2峰）（9，644 +/-1，783对7，538 +/-1，522 μ U。ml（-1）。180 min（-1））。在肥胖的NIDDM受试者中，血糖和胰岛素反应面积在OGTT期间也没有减少改变7天的运动在50或70%Vo（2 peak）.CONCLUSIONS -它的结论是，运动引起的改善胰岛素敏感性的影响，在肥胖个体的运动强度。肥胖者在70%Vo（2峰）运动7天后胰岛素敏感性的改善可能与运动期间更大的肌糖原利用有关。肥胖NIDDM患者在50或70%Vo（2 peak）运动7天后葡萄糖耐量和胰岛素敏感性没有改善，可能是由于本研究中选择的NIDDM患者相对低胰岛素血症。
OBJECTIVE - The primary purpose of this study was to evaluate the acute effect of exercise oi differing intensity on plasma glucose and insulin responses to an oral glucose challenge.RESEARCH DESIGN AND METHODS - Six obese men and six obese men with NIDDM of similar age, weight, percentage body fat, and Vo(2peak) participated in the study. Each subject underwent two 7-day exercise programs in a counterbalanced order al 2-week intervals. During each 7-day exercise period, the subjects cycled every day at a power output corresponding to 50% Vo(2peak) for 70 min or 70% Vo(2peak) for 50 min. Muscle glycogen utilization was estimated during exercise on day 7 using a [H-3]glucose infusion technique in conjunction with indirect calorimetry. During the day before and after each 7-day exercise period, a 3-h oral glucose tolerance test (OGTT) was administered after a 12-h overnight fast.RESULTS - The average caloric expenditure did not differ between exercise at 50 and 70% Vo(2peak) in both obese and obese NIDDM subjects. However, the carbohydrate oxidation was higher (P < 0.05) during exercise at 70 than 50% Vo(2peak) in obese subjects (77 +/- 5 vs. 68 +/- 6 g) and obese NIDDM subjects (70 +/- 4 vs. 58 +/- 6 g Muscle glycogen utilization was also higher (P < 0.05)during exercise at 70 than 50% Vo(2peak) in obese subjects (59 +/- 9 vs. 30 +/- 7 g) and in obese NIDDM subjects (48 +/- 5 vs. 24 +/- 5 g). In obese subjects,plasma glucose response area during the OGTT did not change after 7 days oi exercise at either 50 or 70% Vo(2peak). Plasma insulin response area during the OGTT also did not change after 7 days oi exercise at 50% at 70% Vo(2peak) (9,644 +/- 1,783 vs. 7,538 +/- 1,522 mu U . ml(-1). 180 min(-1)). In obese NIDDM subjects, both plasma glucose and insulin response areas during the OGTT did nor decrease alter 7 days of exercise at either 50 or 70% Vo(2peak).CONCLUSIONS - it is concluded that the exercise-induced improvement in insulin sensitivity is influenced by exercise intensify in obese individuals. The improved insulin sensitivity after 7 days of exercise at 70% Vo(2peak) in obese individuals may be related to greater muscle glycogen utilization during exercise. The lack of improvement in glucose tolerance and insulin sensitivity after 7 days of exercise at either 50 or 70% Vo(2peak) in obese NIDDM patients may be due to the fact that the NIDDM patients selected in the present study were relatively hypoinsulinemic.