The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.
The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.
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DOI：
10.1002/prot.24701
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发表时间：
2014-12
期刊：
影响因子：
2.9
通讯作者：
Veldkamp CT
中科院分区：
文献类型：
--
作者：
Casper SK;Schoeller SJ;Zgoba DM;Phillips AJ;Morien TJ;Chaffee GR;Sackett PC;Peterson FC;Crossgrove K;Veldkamp CT
马来丝虫是一种引起人类淋巴丝虫病的寄生线虫。这里报道了马来布鲁菌 DAF-16a 的叉头 DNA 结合域的溶液结构，马来布鲁菌 DAF-16a 是秀丽隐杆线虫 DAF-16 的推定直系同源物。它被认为是无脊椎动物叉头或有翼螺旋结构域的第一个结构。线虫 DAF-16 参与胰岛素/IGF-I 信号通路，有助于控制新陈代谢、寿命和发育。人类 FOXO 蛋白的序列和结构保守性表明马来芽孢杆菌 DAF-16a 是叉头蛋白 FOXO 家族的成员。
Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggest that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins.