Muscarinic receptors activity in the perirhinal cortex and hippocampus has differential involvement in the formation of recognition memory
Muscarinic receptors activity in the perirhinal cortex and hippocampus has differential involvement in the formation of recognition memory
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DOI：
10.1016/j.nlm.2012.03.006
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发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Bermudez-Rattoni, Federico
中科院分区：
文献类型：
--
作者：
Balderas, Israela;Morin, Jean-Pascal;Bermudez-Rattoni, Federico
在这项工作中，我们探讨了试验后输注毒蕈碱受体拮抗剂东莨菪碱对物体识别记忆形成的影响。东莨菪碱注入双侧后立即在嗅周皮质或背侧海马的样品阶段和动物进行了测试，短期（90分钟）或长期（24小时）的记忆。结果表明，东莨菪碱损害短期记忆时，无论是在嗅周皮质或海马。然而，东莨菪碱干扰长期记忆时，在嗅周皮质，但不适用于海马。东莨菪碱注入160分钟后，样品阶段或90分钟前测试阶段的长期记忆不受影响。我们的数据表明，短期识别记忆需要在嗅周皮层和海马中的毒蕈碱受体信号，而长期识别记忆依赖于嗅周皮层中的毒蕈碱受体，而不是海马。这些结果支持了不同的参与毒蕈碱活性在这两个内侧颞叶结构的识别记忆的形成。(C)2012 Elsevier Inc. All rights reserved.
In this work we probed the effects of post-trial infusions of the muscarinic receptor antagonist scopolamine on object recognition memory formation. Scopolamine was infused bilaterally immediately after the sample phase in the perirhinal cortex or dorsal hippocampus and animals were tested for short-term (90 min) or long-term (24 h) memory. Results showed that scopolamine impaired short-term memory when injected in either the perirhinal cortex or hippocampus. Nevertheless, scopolamine disrupted long-term memory when administrated in the perirhinal cortex but not when applied in the hippocampus. Long-term memory was unaffected when scopolamine was infused 160 min after the sample phase or 90 min before test phase. Our data indicate that short-term recognition memory requires muscarinic receptors signaling in both the perirhinal cortex and hippocampus, whereas long-term recognition memory depends on muscarinic receptors in the perirhinal cortex but not hippocampus. These results support a differential involvement of muscarinic activity in these two medial temporal lobe structures in the formation of recognition memory. (C) 2012 Elsevier Inc. All rights reserved.