Melanotic schwannoma: A case with strong CD34 expression, with histogenetic implications
Melanotic schwannoma: A case with strong CD34 expression, with histogenetic implications
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DOI：
10.1016/j.prp.2010.02.011
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发表时间：
2010-01-01
影响因子：
2.8
通讯作者：
Arvanitis, Leonidas D.
中科院分区：
文献类型：
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作者：
Arvanitis, Leonidas D.
黑色素神经鞘瘤（MS）是一种罕见的肿瘤，由具有神经鞘细胞和黑素细胞特征的细胞组成，通常发生在卡尼复合体的背景下。我们描述了一个36岁男性的病例，他提出了一个肿块，附着在椎体以及L2和L3的神经根。S-100、HMB-45和泛黑色素瘤标记物的免疫组化阳性，以及特征性的形态学和超微结构发现，提示该病变为多发性硬化症。该病例的有趣之处在于，该多发性硬化症表现出强烈的CD34表达，而CD34在黑色素细胞肿瘤中通常是阴性的。我们讨论了肿瘤细胞高CD34表达的生物学意义，并试图阐明这种罕见实体的组织发生。(C) 2010 Elsevier GmbH版权所有。
Melanotic schwannomas (MS) are rare tumors composed of cells with both schwannian and melanocytic features, which usually occur in the setting of Carney's Complex. We describe a case of a 36-year-old male who presented with a mass that was attached to the vertebral body as well as the nerve roots of L2 and L3. Immunohistochemical positivity for S-100, HMB-45, and Pan-melanoma markers, as well as characteristic morphologic and ultrastructural findings, suggested that the lesion was a MS. The interest in this case lies in the fact that this case of MS showed strong CD34 expression, a marker that is generally negative in melanocytic tumors. We discuss the biologic significance of the high CD34 expression by the tumor cells and attempt to shed light on the histogenesis of this rare entity. (C) 2010 Elsevier GmbH. All rights reserved.